99% Pharmacy Grade Enclomiphene High Quality Fast Delivery and Best Price

Enclomiphene More Info

Chemical Profile and Structural Characteristics

Enclomiphene (CAS 15690-57-0) is the trans-isomer of clomiphene citrate, chemically This non-steroidal selective estrogen receptor modulator (SERM) features a triphenylethylene structure with distinct stereochemistry that determines its pharmacological activity. The compound typically presents as a white to off-white crystalline powder with limited aqueous solubility but good solubility in organic solvents including ethanol and dimethyl sulfoxide. Its molecular weight of 406.0 g/mol and specific three-dimensional configuration enable selective interaction with estrogen receptors in different tissues.

Mechanism of Action and Pharmacological Activity

The compound functions as a competitive antagonist at estrogen receptors in the hypothalamus, blocking endogenous estrogen negative feedback and increasing gonadotropin-releasing hormone (GnRH) secretion. This leads to enhanced pituitary release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which stimulate testicular testosterone production and spermatogenesis. Enclomiphene demonstrates pure antagonist activity without the partial agonist effects characteristic of its cis-isomer zuclomiphene. This specific pharmacological profile results in more predictable endocrine responses and reduced estrogenic side effects compared to racemic clomiphene mixtures.

Therapeutic Applications and Clinical Uses

Enclomiphene is primarily investigated for the treatment of hypogonadotropic hypogonadism in men, offering an oral alternative to testosterone replacement therapy that maintains testicular function and fertility. Clinical studies demonstrate its efficacy in increasing testosterone levels while preserving or improving sperm production. Additional applications include the treatment of infertility in men with idiopathic oligospermia and off-label use for the management of certain endocrine disorders. The compound is typically administered in daily oral doses ranging from 12.5 to 25 mg, with treatment duration varying based on therapeutic goals and individual response.

Formulation Development and Bioavailability Considerations

We supply enclomiphene active pharmaceutical ingredient suitable for oral solid dosage forms, primarily immediate-release tablets and capsules. The compound demonstrates good stability in solid state but requires protection from light due to potential isomerization. Formulation strategies focus on enhancing dissolution characteristics through particle size optimization and the use of appropriate disintegrants and surfactants. Our technical data includes compatibility studies with common pharmaceutical excipients, stability profiles under various storage conditions, and guidance on manufacturing processes to ensure consistent product quality and performance.

Quality Specifications and Analytical Controls

Our enclomiphene API meets stringent quality standards with comprehensive specifications including identification by HPLC and FTIR, chiral purity confirmation, assay requirement of 98.0-102.0%, and  of related substances including zuclomiphene and degradation products. Critical quality attributes encompass residual solvents, heavy metals, microbial limits, and specific optical rotation. We employ validated chiral HPLC methods for precise quantification and isomeric purity determination, along with spectroscopic techniques for structural confirmation. Stability-indicating methods ensure accurate monitoring of product quality throughout the shelf life.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.