99% High purity Memantine Power Pharmacy Grade

Memantine More Info

Chemical Profile and Structural Characteristics

Memantine hydrochloride (CAS 19982-08-2) is a low-to-moderate affinity, voltage-dependent, uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, chemically described as 3,5-dimethyladamantan-1-amine. Its unique adamantane backbone provides lipophilic properties that facilitate blood-brain barrier penetration while maintaining favorable pharmacokinetic properties. The compound typically presents as a white to off-white crystalline powder with good aqueous solubility in its hydrochloride salt form and a molecular weight of 215.76 g/mol for the base compound. This specific molecular architecture enables selective interaction with NMDA receptors without complete channel blockade.

Mechanism of Action and Pharmacological Activity

The compound exerts its primary therapeutic effect through voltage-dependent, uncompetitive antagonism of NMDA receptors, preferentially binding to the receptor-operated cation channels when they are open during prolonged depolarization. This mechanism allows normal physiological neurotransmission while preventing excessive calcium influx that leads to excitotoxicity. Memantine demonstrates fast receptor kinetics with rapid blocking and unblocking properties that preserve synaptic plasticity and learning capabilities. Additional mechanisms include mild antagonism of serotonin and nicotinic acetylcholine receptors, contributing to its overall neuroprotective and cognitive-enhancing effects.

Therapeutic Applications and Clinical Uses

Memantine is approved for the treatment of moderate to severe Alzheimer's disease, demonstrating efficacy in preserving cognitive function, reducing clinical deterioration, and improving daily living activities. The compound is also used off-label for various neurological conditions including vascular dementia, Parkinson's disease dementia, and neuropathic pain syndromes. Clinical protocols typically initiate therapy at 5 mg once daily, with gradual titration to a maintenance dose of 10 mg twice daily based on individual tolerance and therapeutic response. Treatment duration is generally long-term, with ongoing assessment of benefits and adverse effects.

Formulation Development and Administration

We supply memantine hydrochloride API suitable for immediate-release and extended-release oral formulations, including tablets and oral solutions. The compound demonstrates excellent compatibility with standard pharmaceutical excipients and maintains stability across various manufacturing processes. Formulation strategies focus on achieving consistent dissolution profiles and minimizing potential gastrointestinal side effects through appropriate release kinetics. Our technical data supports the development of both conventional and specialized delivery systems, with comprehensive guidance on manufacturing processes to ensure product quality and performance.

Quality Specifications and Analytical Controls

Our memantine hydrochloride meets rigorous pharmacopeial standards with comprehensive specifications including identification by IR and HPLC, assay requirement of 98.0-102.0%, and of related substances and impurities. Critical quality attributes encompass residual solvents, heavy metals, microbial limits, and specific tests for crystallinity and polymorphic form. We employ validated HPLC methods with UV detection for precise quantification and impurity profiling, along with spectroscopic techniques for structural confirmation. Stability-indicating methods ensure accurate monitoring of product quality throughout the shelf life under recommended storage conditions.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.