4,6-Dichloro-2-(propylsulfanyl)-5-Pyrimidinamine Dideu

Product Name: 4,6-Dichloro-2-propylthiopyrimidin-5-amine
CAS Number: 145783-15-9
Molecular Formula: C7H9Cl2N3S
Molecular Weight: 238.13 g/mol
Appearance: Off-white to light yellow crystalline powder

Product Description

4,6-Dichloro-2-propylthiopyrimidin-5-amine is a heterocyclic organic compound belonging to the class of chlorinated thiopyrimidines.
It serves as an important synthetic intermediate in both pharmaceutical and agrochemical industries.
Notably, it is a key intermediate in the synthesis of Ticagrelor, an antiplatelet and anticoagulant active pharmaceutical ingredient (API) widely used for cardiovascular disease treatment.
Its dichloro-thiopyrimidine structure also makes it a versatile building block for the preparation of biologically active molecules with enhanced selectivity and stability.

Key Applications
1. Pharmaceutical Intermediate

Acts as a crucial intermediate for the synthesis of Ticagrelor, a potent antiplatelet drug used to prevent blood clots and reduce the risk of stroke and heart attack.

Widely used in the pharmaceutical industry for the development of pyrimidine-based active compounds.

The chlorine and thioether substituents make it highly reactive for nucleophilic substitution and coupling reactions, facilitating complex drug molecule synthesis.

2. Agrochemical Intermediate

Serves as a key precursor for sulfonylurea herbicides and other pyrimidine-based crop protection agents.

Provides excellent chemical stability and reactivity, ensuring efficient synthesis of broad-spectrum herbicides.

3. Fine Chemical and Research Applications

Used in heterocyclic compound synthesis, specialty chemical manufacturing, and research laboratories.

Suitable for applications requiring sulfur- and chlorine-substituted aromatic systems.

Technical Specifications
Property Specification
Appearance Off-white to light yellow crystalline powder
Purity ≥98% or ≥99% (customizable)
Melting Point 110–115°C
Solubility Slightly soluble in ethanol, acetone, and dichloromethane
Stability Stable under normal storage and handling conditions
Packaging & Storage

Packaging: 1kg aluminum foil bag, 25kg fiber drum, or customized according to client requirements.

Storage: Store in a cool, dry, and well-ventilated area. Protect from moisture and direct sunlight.

Shelf Life: 24 months under proper storage conditions.

Safety Information

Handle with standard laboratory precautions.

Avoid contact with eyes and skin; use appropriate protective gear.

Keep away from strong oxidizing agents.

Refer to the Material Safety Data Sheet (MSDS) for detailed safety and handling guidelines.

Why Choose Us

We supply high-purity 4,6-Dichloro-2-propylthiopyrimidin-5-amine, manufactured under ISO/GMP-compliant conditions with strict analytical verification (HPLC, NMR).
Our product is widely used in the pharmaceutical industry, particularly for Ticagrelor synthesis, as well as in agrochemical and fine chemical R&D applications.
We provide custom synthesis services, flexible packaging, and global logistics support to meet your specific production or research requirements.