EU & US Warehouse Zanthoxylum Bungeanum Extract Powder CAS 29946-61-0 WGX-50 Lemairamin

1.  Description

       Chemical properties: Zanthoxylum bungeanum belongs to unsaturated amide compounds, and its molecular structure includes trans acrylamide groups ((2E) - acrylamide), 3,4-dimethoxyphenethyl side chains, and phenyl groups. The core functional group amide bond (- CONH -) gives it certain chemical stability, while the trans double bond structure gives it a specific spatial configuration and biological activity. The chemical properties are relatively stable at room temperature, but hydrolysis reactions are prone to occur under strong acid, strong alkali, or high temperature conditions, and the processing and storage environment needs to be controlled.
       Physical properties: Sichuan pepper extract is a white to light yellow crystalline powder at room temperature, with a rich and spicy aroma unique to Sichuan pepper, and a long-lasting spicy taste. Slightly soluble in water, easily soluble in organic solvents such as ethanol, ether, chloroform, acetone, etc., with good solubility in oils and fats. Its ethanol solution is neutral and has good compatibility with most natural extracts and food additives.
       Natural sources and preparation: Zanthoxylum bungeanum is mainly naturally present in the skin of Sichuan pepper, and is a key substance for the production of spicy flavor in Sichuan pepper. The content varies greatly depending on the variety, place of origin, and harvesting season. In industry, solvent extraction (such as ethanol reflux extraction) combined with column chromatography purification process is commonly used to separate and obtain from Sichuan pepper peel. It can also be prepared by chemical synthesis method. Natural extraction products have more advantages in flavor and efficacy applications because they retain the synergistic active ingredients of Sichuan pepper.

2.  Application

       In the field of food industry, Sichuan pepper extract, as a natural food seasoning and food additive, is widely used in Sichuan cuisine, hot pot, sauces, pickled products and other foods, giving products a unique spicy flavor. At the same time, due to its antibacterial effect, it can be used as a natural preservative to extend the shelf life of food. In addition, it is also used as a functional food ingredient to develop Sichuan pepper flavored healthy foods with specific physiological functions.
     In the fields of medicine and scientific research, Sichuan peppercorn extract, as a natural pharmacological activity research object, is used for mechanism research in pain relief, anti-inflammatory, antioxidant, and metabolic regulation directions. In scientific research, cell models (such as inflammatory cells and pain related nerve cells) and animal models are used to explore their regulatory effects on pain signaling pathways, inflammatory mediator release, and oxidative stress response, providing experimental evidence for the development of natural analgesic and anti-inflammatory drugs.
      In the field of daily chemical and agriculture, Sichuan peppercorn extract is used in small amounts for oral care products (such as spicy toothpaste) or topical soothing preparations due to its antibacterial and mild irritant properties; In the field of agriculture, it can be used as an active ingredient in plant-based pesticides to prepare biopesticides with insect and antibacterial effects for green prevention and control of crop diseases and pests.

3. Main Efficacy

 Analgesic and Anesthetic Effects: Zanthoxylum bungeanum inhibits the transmission of pain signals from nerve endings by acting on TRPV1 ion channels (transient receptor potential vanillic acid subtype 1), while regulating the release of analgesic substances such as endorphins in the body, producing a dual analgesic effect on both central and peripheral pain. It has a relieving effect on various types of pain such as toothache, joint pain, and neuropathic pain, and its effect is mild and not easily resistant to drug resistance.
        Anti inflammatory and antioxidant effects: On the one hand, Sichuan pepper extract can inhibit the nuclear factor kappa B (NF - κ B) and mitogen activated protein kinase (MAPK) signaling pathways, reduce the expression of inflammatory factors such as tumor necrosis factor - α (TNF - α) and interleukin-1 β (IL-1 β); On the other hand, it can clear reactive oxygen species (ROS) in the body, increase the levels of antioxidant substances such as superoxide dismutase (SOD) and glutathione (GSH), and alleviate oxidative stress and inflammatory damage.
     Antibacterial and preservative effects: Sichuan pepper extract has inhibitory effects on various Gram positive bacteria (such as Staphylococcus aureus), Gram negative bacteria (such as Escherichia coli), and fungi (such as Candida albicans). Its mechanism is to destroy the integrity of microbial cell membranes, interfere with cellular metabolic enzyme activity, and thus inhibit microbial growth and reproduction, playing a role in food preservation and daily chemical antibacterial.
    Digestive regulation effect: Sichuan pepper extract can stimulate the oral and gastrointestinal mucosa, promote the secretion of saliva, gastric juice, and pancreatic juice, enhance gastrointestinal peristalsis, improve digestive function, and alleviate problems such as loss of appetite and indigestion; At the same time, it has a certain protective effect on the gastric mucosa, reducing the damage of irritating substances to the gastric mucosa