99% Enclomiphene citrate CAS 7599-79-3 Pharmacy Grade White Raw Power With Best Price

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Enclomiphene citrate is a non-steroidal selective estrogen receptor modulator (SERM) with the specific CAS Registry Number 7599-79-3. It is the more potent trans isomer of clomiphene and is characterized by its tri structure. This specific geometric isomerism is crucial for its biological activity, distinguishing it from its less active counterpart, zuclomiphene. The compound is formulated as a citrate salt to improve its stability and solubility for oral administration.

The pharmacological action of enclomiphene is centered on its ability to act as a competitive antagonist at estrogen receptors within the hypothalamus. By blocking the normal negative feedback of estrogen on the hypothalamic-pituitary-gonadal (HPG) axis, it tricks the body into perceiving a lower level of circulating estrogen. This deception leads to an increased pulsatile release of Gonadotropin-Releasing Hormone (GnRH), which in turn stimulates the pituitary gland to secrete higher levels of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH).

The primary clinical application investigated for enclomiphene citrate is the treatment of male hypogonadism, specifically in men with secondary hypogonadism where the testicular function is intact but the hormonal signaling from the brain is deficient. It is studied as an alternative to testosterone replacement therapy (TRT) because it works by stimulating the body's own natural testosterone production, thereby potentially preserving testicular function and fertility, which are often suppressed by exogenous testosterone.

From a clinical outcomes perspective, studies have shown that enclomiphene can effectively elevate serum testosterone levels into the normal eugonadal range in a significant proportion of treated men. This is achieved while maintaining or even improving semen parameters, a key advantage over traditional TRT. The therapeutic goal is to alleviate the symptoms of low testosterone, such as fatigue, low libido, and depressed mood, through an endogenous mechanism.

Regarding its safety and regulatory status, enclomiphene citrate has been evaluated in numerous clinical trials. Common side effects are generally mild and may include headaches, mood swings, or irritability, which are consistent with its hormonal mode of action. It is important to note that while the racemic mixture, clomiphene citrate, is widely approved for use in female infertility, enclomiphene as a single isomer has been pursued for specific regulatory approval in male hypogonadism but is not yet universally approved for this indication, making it a subject of ongoing clinical interest.

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