99% Purity Raw Peptide Powder Ss-31 to Treat Heart Failure

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    SS-31is an investigational, first-in-class drug. It is a small, synthetic peptide designed to target and improve the function of mitochondria, which are the energy-producing powerhouses within our cells.

The mechanism of action  of SS-31 is highly targeted and revolves around protecting the mitochondria, the energy-producing organelles in our cells. Here's a step-by-step breakdown:

1. 1.Targeting and Entry:​ SS-31 is a cell-penetrating peptide with a positive charge. It is selectively attracted to and accumulates within mitochondria due to the organelle's highly negative internal environment.

2. 2.Binding to Cardiolipin:​ Once inside the mitochondrion, SS-31 specifically binds to a unique phospholipid called cardiolipin. Cardiolipin is found almost exclusively in the inner mitochondrial membrane and is essential for maintaining the proper shape and function of the protein complexes  that make up the electron transport chain .

3. 3.Stabilization and Effect:​ In many diseased or aged states, cardiolipin becomes damaged or loses its structure, causing the ETC complexes to misfold. This misfolding leads to:

   • Electron Leakage: ​ Electrons "leak" from the ETC, which results in the production of harmful reactive oxygen species .

   • Inefficient Energy Production:​ The disrupted flow of electrons reduces the mitochondrion's ability to create ATP , the primary energy currency of the cell.

   By binding to cardiolipin, SS-31 acts as a molecular stabilizer. It helps hold the ETC complexes in their correct configuration, which:

   • Reduces ROS:​ Minimizes electron leakage, thereby drastically lowering oxidative stress.

   • Boosts ATP Production:​ Restores efficient electron flow, leading to optimal ATP synthesis.

   • Protects Mitochondrial Integrity:​ Helps prevent mitochondrial membrane permeability, a key step in cell death.

In simple terms:​ SS-31 functions like a "tune-up" for the cellular engine. It makes the mitochondria run more smoothly, produce more energy, and generate less toxic exhaust .

SS-31 (Elamipretide) primarily exerts its effects by improving mitochondrial function. The beneficial outcomes observed in preclinical and clinical studies can be summarized as follows:

1. Improved Cellular Energy Production:

• Effect:​ SS-31 enhances the efficiency of the mitochondrial electron transport chain, leading to a significant increase in ATP (adenosine triphosphate) synthesis.

• Outcome:​ Cells have more energy to perform their normal functions. This is crucial for highly energetic tissues like heart muscle, skeletal muscle, and nerves.

2. Reduction in Oxidative Stress:

• Effect:​ By stabilizing the electron transport chain, SS-31 minimizes "electron leak," which is a primary source of harmful reactive oxygen species (ROS).

• Outcome:​ It protects cellular components (like proteins, lipids, and DNA) from oxidative damage, which is a key factor in aging and many diseases.

3. Protection Against Cell Death:

• Effect:​ SS-31 helps maintain the integrity of the mitochondrial membrane, preventing the release of pro-death signals that trigger apoptosis (programmed cell death).

• Outcome:​ It promotes cell survival, particularly in stressed or vulnerable tissues.

4. Improved Cellular Function and Viability:

• Combined Effect:​ The increase in energy and decrease in damage work together to improve the overall health and function of cells.

Potential Therapeutic Effects in Specific Tissues:

• Muscle:​ Reduced fatigue, improved exercise tolerance, and enhanced muscle strength.

• Heart:​ Improved cardiac function and protection against damage in conditions like heart failure.

• Eyes (Retina):​ Protection of retinal cells from degeneration, potentially slowing the progression of diseases like dry Age-related Macular Degeneration.

• Nerves:​ Protection of neurons from damage, with potential applications in neurodegenerative diseases.

SS-31  is being investigated for a range of diseases where mitochondrial dysfunction is a key factor. Its applications can be divided into several areas:

1. Primary Mitochondrial Diseases (The primary focus)

2. Ocular Diseases

3. Cardiovascular Diseases

4. Neurodegenerative Diseases (Mostly in preclinical research)

5. Other Areas

    HaiKou Mingheng Technology Co., Ltd. was founded in 2019 has strong research and development capabilities and superb synthesis technology, as well as advanced quality control measures. We effectively promote joint ventures and cooperation with major enterprises and manufacturers, and serve the society and the majority of users with the idea of industrialized development. We always adhere to the market demand-oriented, and constantly synthesize new chemical products and pharmaceutical intermediates with high technical content, mainly exported to the United States, India, South Africa, Nigeria and many other countries and regions, with rich experience in export, to ensure the safety of transportation, and to be able to let every customer receive the goods safely as early as possible.