High Quality Pure 98% HPLC Lysyl oxidase inhibitor LXG6403 CAS 315705-04-5

LXG6403 is a potent, competitive, and irreversible lysyl oxidase (LOX) inhibitor (IC50 value of 1.3 μM), exhibiting approximately 3.5-fold specificity for LOX compared to LOXL2, while not inhibiting LOXL1. LXG6403 demonstrates favorable pharmacokinetic properties, comprehensively altering ECM/collagen structure and reducing tumor rigidity. This leads to better drug penetration, inhibition of FAK signaling, and induction of ROS/DNA damage, G1 phase arrest, and apoptosis in chemotherapy-resistant triple-negative breast cancer (TNBC) cell lines, PDX organoids, and in vivo.

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