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Ethyl thiooxamate 16982-21-1

Name: Ethyl thiooxamate 16982-21-1
Brand: Orient
SKU: pr2511271611
Price: 5 USD
Availability: InStock

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CAS No.:

16982-21-1

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-27

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information

Description

Ethyl thiooxamate Basic information

Product Name:	Ethyl thiooxamate
Synonyms:	aminothioxoacetic acid ethyl ester;thiooxamic acid ethyl ester;ETHYL AMINOTHIOXOACETATE;ETHYL THIOOXAMATE;ETHYL THIOOXAMIDATE;ETHYL THIOXAMATE;amino(thioxo)acetate;Acetic acid, 2-amino-2-thioxo-, ethyl ester
CAS:	16982-21-1
MF:	C4H7NO2S
MW:	133.17
EINECS:
Product Categories:	Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds;Aliphatics;Metal Isotopes;Sulfur & Selenium Compounds;Miscellaneous;john's
Mol File:	16982-21-1.mol

Ethyl thiooxamate Chemical Properties

Melting point	62-65 °C (lit.)
Boiling point	199.2±23.0 °C(Predicted)
density	1.226 (estimate)
refractive index	1.5480 (estimate)
Fp	74°
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	chloroform: soluble25mg/mL, clear to slightly hazy (colorless to orange)
pka	11.31±0.29(Predicted)
form	Crystalline Powder
color	Yellow
InChI	InChI=1S/C4H7NO2S/c1-2-7-4(6)3(5)8/h2H2,1H3,(H2,5,8)
InChIKey	YMBMCMOZIGSBOA-UHFFFAOYSA-N
SMILES	C(OCC)(=O)C(N)=S
CAS DataBase Reference	16982-21-1(CAS DataBase Reference)

Ethyl thiooxamate Usage And Synthesis

Chemical Properties	Yellow Needles
Uses	Ethyl thiooxamate is used in a synthesis of functionalized bithiazoles.
Uses	Ethyl thiooxamate was used in the synthesis of functionalized bithiazoles.
Synthesis	623-49-4 16982-21-1 The general procedure for the synthesis of ethyl thiooxalate from ethyl cyanoformate was as follows: [(cyanocarbonyl)oxy]ethane (25 g, 0.25 mol) was dissolved with triethylamine (1 ml) in ether (200 ml) and cooled to 0°C. H2S gas was drummed into the solution for 2 hours. After completion of the reaction, the mixture was stirred at room temperature overnight, followed by replacement of the gas in the reaction system with N2. A 1N HCl solution (200 ml) was added and stirring was continued for 30 minutes. The reaction mixture was separated by extraction with ether. The organic layer was washed with brine and dried with anhydrous MgSO4. The desiccant was removed by filtration and the solvent was evaporated under reduced pressure to give ethyl thiooxalate as a yellow solid (32 g, 95% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 1.37 (t, J = 7.14 Hz, 3H), 4.34 (q, J = 7.14 Hz, 2H), 7.49-8.43 (m, 2H). m/z 134 (M + H)+ was shown by LC-MS (ESI) analysis.
References	[1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 19 [2] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3021 - 3026 [3] Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983, vol. 38, # 3, p. 335 - 340 [4] Organic Syntheses, 1988, vol. 66, p. 142 - 142 [5] Patent: WO2005/37804, 2005, A1. Location in patent: Page/Page column 10

Ethyl thiooxamate Preparation Products And Raw materials

Raw materials	ETHYL OXAMATE-->Ethyl cyanoformate-->Hydrogen Sulfide-->Diethyl ether-->Triethylamine
Preparation Products	4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER-->2,4-Thiazoledicarboxylic acid,2-ethyl ester-->Ethyl 4,5-dimethyl-1,3-thiazole-2-carboxylate-->2-Thiazolecarboxylic acid,4-(4-bromophenyl)-,ethyl ester-->Ethyl 4,5-bis(4-methoxyphenyl)thiazole-2-carboxylate-->2-Thiazolecarboxylic acid, 4-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-, ethyl ester-->Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

ECHEMI Editorial Reference

Yellow Needles

Certificates

Basic Info

Product Name:

Ethyl thiooxamate

Other Name:

Acetic acid,2-amino-2-thioxo-,ethyl ester;Oxamic acid,2-thio-,ethyl ester;Acetic acid,aminothioxo-,ethyl ester;Ethyl thiooxamidate;Ethyl 2-thiooxamate;Ethyl amino(thiocarbonyl)carboxylate;Ethyl thiooxamate;Ethyl 2-amino-2-thioxoacetate;Ethyl aminothioxoacetate;NSC 174676;Ethyl thioxamate;Ethyl thiocarbamoylformate;Thiooxamic acid ethyl ester;2-Thiooxamic acid ethyl ester;(Amino)(thioxo)acetic acid ethyl ester;2-Amino-2-thioxoacetic acid ethyl ester;Ethyl 2-amino-thioxoacetate;1770851-49-4

CAS No.:

16982-21-1

Molecular Formula:

C4H7NO2S

InChIKeys:

InChIKey=YMBMCMOZIGSBOA-UHFFFAOYSA-N

Molecular Weight:

133.17

Exact Mass:

133.17

EC Number:

605-564-7

NSC Number:

174676

DSSTox ID:

DTXSID70369893

HScode:

29309090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

84.4

XLogP3:

0.4

Appearance:

Yellow Crystalline Powder

Density:

1.226 (estimate)

Melting Point:

58-60 °C @ Solvent: Ethanol

Boiling Point:

199.2±23.0 °C(Predicted)

Flash Point:

74.2±22.6 °C

Refractive Index:

1.5480 (estimate)

Water Solubility:

chloroform: soluble25mg/mL, clear to slightly hazy (colorless to orange)

Storage Conditions:

Freezer (-20°C)

Vapor Pressure:

0.0207mmHg at 25°C

See More Ethyl thiooxamate Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Ethyl thiooxamate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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