2-Ethoxy-4-amino-5-chlorobenzoic acid 108282-38-8

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2-Ethoxy-4-amino-5-chlorobenzoic acid Basic information

Product Name:	2-Ethoxy-4-amino-5-chlorobenzoic acid
Synonyms:	2-ETHOXY-4-AMINO-5-CHLOROBENZOIC ACID;4-AMINO-5-CHLORO-2-ETHOXYBENZOIC ACID;3-Carbomethoxy-1-chloro-4-methoxyanaline;4-amino-5-chloro-2-ethoxy-benzoic acid (intermediate of mosapride citrate );METHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE;4-Amino-5-Chloro-2-Ethoxy Benzoic Acid 2-Ethoxy-4-Amino-5-Chlorobenzoic Acid;Mosapride Impurity 9;Benzoic acid,4-aMino-5-chloro-2-ethoxy-
CAS:	108282-38-8
MF:	C9H10ClNO3
MW:	215.63
EINECS:	600-861-8
Product Categories:	Pharmaceutical Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;(intermediate of mosapride citrate );Aromatics Compounds
Mol File:	108282-38-8.mol

2-Ethoxy-4-amino-5-chlorobenzoic acid Chemical Properties

Melting point	165-169°C
Boiling point	377.7±42.0 °C(Predicted)
density	1.376±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	4.50±0.10(Predicted)
color	White to Light Yellow
InChI	InChI=1S/C9H10ClNO3/c1-2-14-8-4-7(11)6(10)3-5(8)9(12)13/h3-4H,2,11H2,1H3,(H,12,13)
InChIKey	XWGYOMHQGQZRLC-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC(Cl)=C(N)C=C1OCC
CAS DataBase Reference	108282-38-8(CAS DataBase Reference)

Safety Information

HS Code

2922.50.4000

2-Ethoxy-4-amino-5-chlorobenzoic acid Usage And Synthesis

Chemical Properties	White or almost white powder
Uses	Methyl 4-Amino-5-chloro-2-methoxybenzoate is used in preparation of phenoxymethylpyridine derivatives as immunomodulators. 4-amino-5-chloro-2-ethoxybenzoic acid is mainly used in the field of pharmaceutical intermediates and is a key intermediate for the synthesis of gastrointestinal motility drug Mosapride. ‌ Application of pharmaceutical intermediates This compound can be synthesized into mosapride through steps such as acidification, esterification, amidation, O-ethylation, chlorination, and hydrolysis. The latter is used to treat gastrointestinal motility disorders such as functional dyspepsia and gastroesophageal reflux disease. ‌ Other potential uses As an organic synthesis intermediate, it may participate in the synthesis of other drugs or chemicals, but specific applications need to be combined with downstream product requirements.
Synthesis Reference(s)	Chemical and Pharmaceutical Bulletin, 19, p. 1696, 1971 DOI: 10.1248/cpb.19.1696

2-Ethoxy-4-amino-5-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

4-(1,3-dioxoisoindol-2-yl)-2-hydroxy-benzoic acid-->Ethopabate-->4-ACETAMINO-5-CHLORO-2-ETHOXY METHYL BENZOATE-->METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE-->Sodium 4-aminosalicylate-->METHYL 4-AMINOSALICYLATE-->4-Aminosalicylic acid



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