2-CYCLOHEXYLETHYL BROMIDE 1647-26-3

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2-CYCLOHEXYLETHYL BROMIDE Basic information Product Name: 2-CYCLOHEXYLETHYL BROMIDE Synonyms: 2-CYCLOHEXYLETHYL BROMIDE;1-BROMO-2-CYCLOHEXYLETHANE;(2-bromoethyl)-cyclohexane;Cyclohexane, (2-bromoethyl)-;cyclohexane,(2-bromoethyl)-;1-Bromo-2-cyclohexylethane~(2-Bromoethyl)cyclohexane;2-Cyclohexylethyl bromide,98%;NSC 46808 CAS: 1647-26-3 MF: C8H15Br MW: 191.11 EINECS: 216-712-1 Product Categories: Mol File: 1647-26-3.mol 2-CYCLOHEXYLETHYL BROMIDE Chemical Properties Melting point  57°C Boiling point  209 °C (lit.) density  1.221 g/mL at 25 °C (lit.) refractive index  1.4900 Fp  96°C storage temp.  Inert atmosphere,Room Temperature solubility  Chloroform (Sparingly), Ethyl Acetate (Slightly) form  Liquid color  Clear colorless to slightly yellow BRN  1919816 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. InChIKey JRQAAYVLPPGEHT-UHFFFAOYSA-N CAS DataBase Reference 1647-26-3(CAS DataBase Reference) EPA Substance Registry System Cyclohexane, (2-bromoethyl)- (1647-26-3) Safety Information Risk Statements  36/38 Safety Statements  26-36 WGK Germany  3 HS Code  29021900 2-CYCLOHEXYLETHYL BROMIDE Usage And Synthesis Chemical Properties 2-CYCLOHEXYLETHYL BROMIDE is colourless to yellow liquid Uses 2-CYCLOHEXYLETHYL BROMIDE is a reagent used in the cross-coupling and Grignard reactions. It is used in the synthesis of immunosuppressive agents consisting of 5-phenylalkoxypsoralens as well as agon ists for human vitamin-D resistant Rickets. Uses 1-Bromo-2-cyclohexylethane may be used in the synthesis of 2-cyclohexylethyloxy-4-nitroaniline. General Description 1-Bromo-2-cyclohexylethane is a halogenated hydrocarbon. Reaction of 1-bromo-2-cyclohexylethane with pillar[5]arene has been investigated. Synthesis 4442-79-9 1647-26-3 General procedure for the synthesis of 2-cyclohexylethane bromoethane from 2-cyclohexylethanol: In a 1-liter round-bottomed flask fitted with a reflux condenser, 88.7 g (0.693 mol) of 2-cyclohexylethanol was added, followed by the slow addition of 164 g of concentrated sulfuric acid and 200 g of hydrobromic acid (48% aqueous), cooled in an ice bath. The reaction mixture was heated to reflux for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of 400 g of ice. The aqueous phase was extracted with 400 ml of pentane and the organic layers were combined. The organic layer was washed sequentially with 2M NaOH solution and water and then dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the product was finally purified by vacuum distillation to give 112.7 g (85% yield) of 2-cyclohexylethyl bromide as a colorless oil.1H-NMR (400 MHz, CDCl3): δ= 3.40 (2H, t, CH2Br), 1.73-1.61 (m, 7H), 1.44 (m, 1H), 1.26-1.11 ( m, 3H), 0.92-0.84 (m, 2H) ppm. References [1] Journal of Medicinal Chemistry, 2011, vol. 54, # 6, p. 1693 - 1703 [2] Patent: US8299287, 2012, B2. Location in patent: Page/Page column 43 [3] Patent: JP6196581, 2017, B2. Location in patent: Paragraph 0156 [4] Journal of Medicinal Chemistry, 1992, vol. 35, # 12, p. 2253 - 2260 [5] Bulletin de la Societe Chimique de France, 1948, p. 586,588 2-CYCLOHEXYLETHYL BROMIDE Preparation Products And Raw materials Raw materials Cyclohexanepropionic acid-->2-Cyclohexylethanol-->Sulfuric acid-->Hydrogen bromide Preparation Products 2-CYCLOHEXYL-ETHYLAMINE HYDROCHLORIDE



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