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Ivacaftor Impurity 873054-44-5

Unit Price:

$100/G FOB

Get Latest Price
CAS No.:

873054-44-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

qingdao

Brand:

JF

Packaging:

according to your request

Price valid (until):

2029-11-21

Company Type:
Trader
Location:
Hongkong, China
Qualification:
Main Products:

Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

  • Product Description

  • Seller Information

  • Description

    API powder Ivacaftor (VX-770) with CAS 873054-44-5

    Item Name Ivacaftor 
    CAS NO 873054-44-5 
    Apparence White Powder
    Package Aluminum Bag;Drums;Paper Box Outside
    Shipment FedEx;DHL;UPS;TNT;EMS;Sea;Air.
    Payment T/T;Trade Assurance;L/C
    Warranty 2 Years

     

    Item Specification 
    Specific rotation +39.5 to +41.5° 
    State of solution(transmittance) Clear 98.0% min.
    Chloride[cl] 0.020% max. 
    Ammonium [NH4] 0.02% max. 
    Sulfate[SO4] 0.020% max
    Iron[Fe] 10ppm max.
    Heavy metals [Pb] 10ppm max
    Arsenic[As2O3] 1ppm max
    Other amino acids Chromatographically not detectable
    Loss on drying 0.20% max. 
    Residue on ignition[sulfated] 0.10% max.
    Assay 99.0% min

     

    Function and Application

    Ivacaftor is a new therapeutic agent that acts at the cystic fibrosis transmembrane conductance regulator (CFTR) channel to alter activity. It is approved for use in patients 6 years and older with cystic fibrosis who have at least 1 G551D mutation in the CFTR gene. It is unlike any other current pharmacologic agent for cystic fibrosis in that it specifically targets the gene defect associated with cystic fibrosis as opposed to treating resulting symptomology. Mucoactive agents, antibiotics, inhaled beta agonists, and other anti-inflammatory agents are currently the mainstay of cystic fibrosis treatment but can be associated with several side effects in addition to cumbersome frequency of administration. Ivacaftor's oral dosing regimen offers a more convenient treatment option.

    Shop API Vx-770, Synthetic Pharmaceutical CAS 873054-44-5 Ivacaftor Powder-Detailed Image 1

    Packing:

    1. Shop Factory supply Heart Protection Hot Sales Mavacamten CAS 1642288-47-8-Detailed Image 2

    Shop OEM Private Label Supply Weight Loss Fat Burning Peptide Slu-PP-332 powder-Detailed Image 2 Shop OEM Private Label Supply Weight Loss Fat Burning Peptide Slu-PP-332 powder-Detailed Image 3



    FAQ

    Q1: Are you the manufacturer or trade company?
    --We are the manufacturer in China, founded on 2011.

    Q2: When will the product be shipped after payment?
    --The parcel will be get ready and shipped within 1 day.

    Q3: How long will it take to receive the parcel?
    --3-5days for the US market; 3-7days for the others.

    Q4: What can I do if I don't have the ability to clear the custom.
    --We got experience after doing export for many years, so don't worry we can handle that.

    Q5: Why should you buy from us not from other suppliers?
    ---Jinan Jianfeng Chemical Co.,Ltd is a medium-sized enterprise integrating the development, production, sales and export and import trade of chemical products. Our factory has perfect infrastructure, advanced processing technology and completed detection means.

    Basic Info
    Product Name:

    Ivacaftor

    Other Name:

    3-Quinolinecarboxamide,N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-;N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide;VX 770;Ivacaftor;Kalydeco;N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide;N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide;N-[2,4-Di(tert-butyl)-5-hydroxyphenyl]-4-oxo-1H,4H-quinoline-3-carboxamide;1174930-71-2

    CAS No.:

    873054-44-5

    Molecular Formula:

    C24H28N2O3

    InChIKeys:

    InChIKey=PURKAOJPTOLRMP-UHFFFAOYSA-N

    Molecular Weight:

    392.49100

    Exact Mass:

    392.49

    UNII:

    1Y740ILL1Z

    DSSTox ID:

    DTXSID00236281

    ATC Code:

    R07AX30|R07AX02|R07AX31|R07AX|R - Respiratory system

    HScode:

    29333990

    Categories:

    Other Chemical Drugs

    Characteristics
    PSA:

    85.68000

    XLogP3:

    5.6

    Appearance:

    Solid

    Density:

    1.187 g/cm3

    Melting Point:

    212-215

    Boiling Point:

    550.4ºC at 760 mmHg

    Flash Point:

    286.7ºC

    Refractive Index:

    1.606

    Water Solubility:

    H2O: <0.05 µg/mL

    PKA:

    11.08, 1.5

    Dissociation Constants:

    11.08, 1.5

    Hazard Identification

    Classification of the substance or mixture

    Reproductive toxicity, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H361 Suspected of damaging fertility or the unborn child

    Precautionary statement(s)
    Prevention

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

    Location:

    Unit D01,3/F., Wong King Industrial Building,No.2 Tai Yau Street, Kowloon

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $50 million-$100 million

    Total Employees:

    51-100

    Year of Establishment:

    2012

    We have more than 10 years experience in the pharmacy filed. Mainly manufactures pharmaceutical APIs,Pharmaceutical intermediate and Cosmetic raw material. Owing to the good quality and competitive price, we have a very good reputation in China's pharmaceutical circles.

    In the principle of "Quality Oriented", Jianfeng passed the certification of ISO9001:2008 Quality Management System.

    Our products are based on bulk, high volume, wholesale price, third party testing, certificate reporting, and bring high quality ingredients to many domestic and overseas enterprises.

    "Honesty, practicality, innovation, development" are our values. Jianfeng would like to cooperate with you with high quality products and competitive price.

  • Country Product Purchase Quantity Date Posted
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