Nootropics 99% Dihexa Peptide 20mg Vials CAS 1401708-83-5 Pure Dihexa

1.  Description

Chemical properties: Dihexa belongs to the linear heptapeptide compound, with core functional groups of peptide bonds, amino groups, and carboxyl groups. As a receptor antagonist for corticotropin releasing factor (CRF), it can specifically block the anxiety signaling pathway mediated by CRF, and does not have the receptor binding properties of benzodiazepines. The chemical properties are stable, and it is not easily hydrolyzed by peptidases in neutral to weakly acidic (pH 5.0-7.0) environments. Its half-life is 3-4 times longer than that of natural thymic peptide fragments, and it has good compatibility with neurotrophic components such as vitamin B family and phosphatidylserine.
     Physical properties: Dihexa is a white to off white crystalline powder at room temperature, odorless and tasteless, with excellent water solubility (solubility ≥ 60 mg/mL). It can quickly dissolve in aqueous systems such as pure water, physiological saline, and phosphate buffered saline (PBS), and is slightly soluble in ethanol and propylene glycol, but insoluble in non-polar solvents such as ether and petroleum ether. Store under dry, sealed, and dark conditions at 2-8 ℃ to avoid repeated freezing and thawing; The purity of research grade/application grade products is ≥ 98% (detected by HPLC), with single impurities ≤ 1.0% and no residual endotoxins.
       Source and preparation: Dihexa has no natural form and is precisely prepared by solid-phase peptide synthesis. Using high-purity L-type amino acids as raw materials, the target sequence is constructed through multi-step reactions such as condensation, deprotection, and peptide chain assembly, and finally purified by high performance liquid chromatography (HPLC) to obtain high-purity products; The synthesis process strictly controls the reaction temperature (25-30 ℃) and feeding ratio to ensure the integrity of the peptide chain structure and neural regulatory activity.

2.  Application

      In the field of biomedical research, Dihexa serves as a core tool and reagent for the study of neural regulatory mechanisms, used to explore the mechanisms of anxiety disorders, cognitive decline, post-traumatic stress disorder (PTSD), and neurodegenerative diseases such as mild cognitive impairment (MCI). By using animal models such as rats and mice, as well as in vitro models of nerve cells (such as hippocampal neurons), analyze their regulatory effects on the CRF pathway and brain-derived neurotrophic factor (BDNF) expression, providing experimental evidence for the development of neuropharmaceuticals.
    In the field of high-end functional supplements, Dihexa is used as a neurohealth ingredient to develop dietary supplements such as capsules, freeze-dried powder, sublingual tablets, etc., targeting high-pressure workplace populations (relieving anxiety and mental fatigue), middle-aged and elderly populations (improving mild cognitive decline), and exam preparation/high-intensity brain users (improving attention and memory). Its small molecular structure (molecular weight 751.9 Da) can pass through the blood-brain barrier (permeability of about 12%) and can be absorbed without digestion and decomposition, meeting the compliance standards for dietary supplements in the European Union and the United States.
    Potential skin repair and medical beauty field: Dihexa can be added to medical art post repair products (such as photon rejuvenation, post microneedle essence/face cream) based on anti-inflammatory and immune regulatory properties to alleviate postoperative skin redness and inflammatory reaction; It can also be used in sensitive skin repair products to improve redness and itching caused by neurogenic inflammation by regulating the skin's neuroimmune pathway. Currently, the relevant applications are in the preclinical validation stage.

3. Main Efficacy

Anti anxiety and emotion regulation effects: The core mechanism of Dihexa is the competitive binding of CRF1 receptors in the central nervous system, blocking CRF mediated anxiety signal transduction, while upregulating the release of gamma aminobutyric acid (GABA) in the hippocampus to balance neural excitability. Animal experiments have shown that Selank can significantly reduce the elevated maze anxiety score of anxiety model mice, without the sedative and drowsiness side effects of benzodiazepines, as well as addiction and withdrawal reactions.
    Cognitive enhancement and neuroprotective effects: Dihexa activates the proliferation and synaptic plasticity of hippocampal neurons by promoting the expression of brain-derived neurotrophic factor (BDNF), improving learning and memory abilities, attention, and information processing speed; Simultaneously clearing reactive oxygen species (ROS) in nerve cells, inhibiting neuronal apoptosis, protecting hippocampal neurons from oxidative stress and glutamate excitotoxicity damage, and improving cognitive decline caused by aging or mild brain injury.
        Anti inflammatory and immune regulatory effects: Dihexa inhibits the release of peripheral and central pro-inflammatory factors (such as TNF - α, IL-6), regulates the activity of monocytes and lymphocytes, and balances the body's immune response; At the skin level, it can inhibit neurogenic inflammation (such as calcitonin gene-related peptide CGRP mediated redness), repair the skin's neuroimmune barrier, alleviate repeated redness and stinging of sensitive muscles, and can shorten the time for inflammation to subside by more than 25% after medical treatment.
       Safety advantages: Dihexa has no cytotoxicity (MTT assay shows that the survival rate of nerve cells is>97% when the concentration is ≤ 2 mg/mL), no mutagenicity, no reproductive toxicity, and no significant adverse reactions after long-term low-dose use; Compared to traditional anti anxiety drugs, it does not affect motor coordination and cognitive clarity, and is suitable for long-term daily use scenarios.