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L-(+)-Ergothioneine 497-30-3

Name: L-(+)-Ergothioneine 497-30-3
Brand: Orient
SKU: pr2512181123
Price: 4 USD
Availability: InStock

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CAS No.:

497-30-3

Grade:

Industrail Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-18

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	L-(+)-Ergothioneine
Synonyms:	L-(+)-ERGOTHIONEINE INNER SALT;ERGOLD;2-MERCAPTOHISTIDINE BETAINE;(S)-ALPHA-CARBOXY-2,3-DIHYDRO-N,N,N-TRIMETHYL-2-THIOXO-1H-IMIDAZOLE-4-ETHANAMINIUM INNER SALT;THIONEINE;(S)-[1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethylammonium hydroxide;1H-Imidazole-4-ethanaminium, .alpha.-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (.alpha.S)-;3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-trimethylammonio-propanoate
CAS:	497-30-3
MF:	C9H15N3O2S
MW:	229.3
EINECS:	207-843-5
Product Categories:	Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;cosmetics;nutrition supplement
Mol File:	497-30-3.mol

L-(+)-Ergothioneine Chemical Properties

Melting point	275-277°C (dec.)
density	1.2541 (rough estimate)
refractive index	1.6740 (estimate)
storage temp.	-20°C
solubility	Soluble in Water (up to 10 mg/ml)
pka	1.706±0.32(predicted)
form	White solid.
color	White or off-white
PH	+47^o (c=1 in water)
biological source	fungus (Actinomycetales) fungus (Ascomycota) fungus (Basidiomycota)
Water Solubility	water: 50mg/mL, clear, colorless
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for no more then 1 day.
Cosmetics Ingredients Functions	SKIN CONDITIONING - MISCELLANEOUS ANTIOXIDANT
InChI	InChI=1/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/s3
InChIKey	SSISHJJTAXXQAX-KPOCXSGKNA-N
SMILES	[N+](C)(C)(C)[C@@H](CC1=CNC(S)=N1)C([O-])=O \|&1:4,r\|
EPA Substance Registry System	1H-Imidazole-4-ethanaminium, .alpha.-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (.alpha.S)- (497-30-3)

Safety Information

WGK Germany	3
HS Code	2933299090

MSDS Information

L-(+)-Ergothioneine Usage And Synthesis

Description	L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine via hercynine. Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression. In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine. Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.
Chemical Properties	White Solid
Uses	L-(+)-Ergothioneine is a natural molecule isolated from the rye ergot fungus and later identified in rat erythrocytes and liver and in numerous other animal tissues. Its antioxidizing properties may afford the compound therapeutic potential or it may be used as a food additive or in cosmetics.
Definition	ChEBI: Ergothioneine is a L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine synthesized by bacteria and fungi with antioxidant properties. It is found ubiquitously in plants and animals and is present in many human foodstuffs. It has a role as an antioxidant, a fungal metabolite, a plant metabolite, a xenobiotic metabolite and a chelator. It is an amino-acid betaine, a L-histidine derivative and a sulfur-containing amino acid. It is a conjugate base of an ergothioneine(1+). It is a tautomer of an ergothioneine thione form.
Origin	Ergothioneine was discovered in 1909 by Charles Tanret, a French pharmacist and chemist. Tanret was examining the ergot fungus, which had recently been responsible for destroying crops, and he discovered the compound by using a purification process. The amino acid name ergothioneine originates from this fungus. Though this discovery is relatively recent, scientists speculate that ergothioneine may have originated from ancient earth. Due to its anaerobic nature (it does not require oxygen to function), it may have manifested in the earth's oxygen-free atmosphere more than three billion years ago While ergothioneine is not classified as one of the nine essential amino acids.
benefits	L-(+)-Ergothioneine is a natural antioxidant, which has various physiological functions such as scavenging free radicals, detoxification, maintaining DNA biosynthesis, normal cell growth and cellular immunity.
General Description	L-(+)-Ergothioneine (ERG) is a substance that cannot be synthesized by humans and must be obtained from food. It has cytoprotective and antioxidant properties.
Source	L-(+)-Ergothioneine (ET) is a sulfur-containing amino acid, which is only produced by Actinomycetales bacteria and non-yeast like fungi belonging to the division Basidiomycota and Ascomycota. It was originally isolated from Claviceps purpurea or rye ergot. It is obtained from L-histidine, which is converted into betaine form called hercynine. It is found in both animals and plants, and mammals usually obtain it from their diet, e.g. through mushrooms or oats. It is tautomeric in nature, and in neutral aqueous solution exists in thione form.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Ergothioneine

Other Name:

1H-Imidazole-4-ethanaminium,α-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-,inner salt,(αS)-;1H-Imidazole-4-ethanaminium,α-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-,hydroxide,inner salt,(S)-;Ammonium,[1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethyl-,hydroxide,inner salt,L-(+)-;Ergothioneine;Sympectothion;Thiasine;Thioneine;Histidine,2-mercapto-,trimethylbetaine;Histidine,2-mercapto-N,N-dimethyl-,betaine;L-Ergothioneine;2-Mercapto-N,N-dimethylhistidine methyl ester betaine;2-Mercaptohistidine trimethylbetaine;Ergothionine;1H-Imidazole-4-ethanaminium,α-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-,inner salt,(S)-;2-Mercaptohistidine betaine;NSC 7175;Thiotane;thiotaine;Phytothioneine;(S)-5-(2-Carboxy-2-(trimethylammonio)ethyl)-1H-imidazole-2-thiolate;(2S)-3-(2-Sulfanyl-1H-imidazol-4-yl)-2-(trimethylazaniumyl)propanoate;616-50-2;644-57-5;6330-63-8

CAS No.:

497-30-3

Molecular Formula:

C9H15N3O2S

InChIKeys:

InChIKey=SSISHJJTAXXQAX-ZETCQYMHSA-N

Molecular Weight:

229.3

Exact Mass:

229.088501

EC Number:

207-843-5

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

96.3

XLogP3:

0.3

Appearance:

Solid

Density:

1.2541 (rough estimate)

Melting Point:

280 °C (decomp)

Storage Conditions:

-20ºC

See More Ergothioneine Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Ergothioneine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

9 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	L-Ergothioneine	1 KG	Jul 4, 2025
Singapore	Ergothioneine 99% white powder	10 MG	Mar 18, 2024
India	Ergothioneine 99% white powder	0.025 G	Jan 18, 2024
Denmark	ergothioneine	1 MT	Dec 2, 2024
Greece	Ergothioneine	1 KG	Apr 12, 2024
India	Ergothioneine	1 KG	Mar 12, 2024
Canada	L-(+)-Ergothioneine	10 G	Sep 9, 2023
Canada	L-Ergothioneine 99% Powder Pharmacy Grade C9H15N3O2S Top Purity Senwayer	10 G	Sep 8, 2023
India	Ergothioneine	25 KG	Nov 4, 2024

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