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Best Quality Palbociclib CAS:571190-30-2 for Anti-breast Cancer

Name: Best Quality Palbociclib CAS:571190-30-2 for Anti-breast Cancer
Brand: HyperChem
SKU: pr2512251503
Price: 20 USD
Availability: InStock

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Unit Price:

$20-25/G FOB

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CAS No.:

571190-30-2

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/bag, 5kg/bag, 25kg/Drum

Price valid (until):

2027-02-28

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Palbociclib
CAS number	571190-30-2
Synonym	Palbociclib 571190-30-2 PD-0332991 PD0332991
Related APIs #	Calcium Orotate (CAS: 22454-86-0) Potassium Orotate (CAS:24598-73-0) Magnesium Orotate (CAS:34717-03-8) Zinc Orotate (CAS:68399-76-8)
Description	Palbociclib: An Overview of Its Mechanism and Applications Palbociclib is a prominent member of the cyclin-dependent kinase (CDK) 4/6 inhibitor class, primarily utilized in the treatment of certain types of breast cancer. This overview aims to delve into the mechanism of action, clinical applications, and potential benefits of Palbociclib, emphasizing its role in targeted cancer therapy. Mechanism of Action Palbociclib operates by selectively inhibiting CDK4 and CDK6, enzymes that are crucial for cell cycle progression. Under normal circumstances, these kinases facilitate the transition from the G1 phase to the S phase of the cell cycle. By inhibiting these kinases, Palbociclib effectively halts cell cycle progression in cancer cells, thereby suppressing tumor growth. This targeted approach is particularly beneficial in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer, where overactivity of CDK4/6 is often observed, leading to uncontrolled cell proliferation. Clinical Applications Palbociclib is predominantly prescribed for the treatment of HR+, HER2- advanced or metastatic breast cancer, typically in postmenopausal women. It is often used in conjunction with endocrine therapy, such as letrozole or fulvestrant, which enhances its efficacy by further targeting hormone receptor signaling pathways. The combination therapy results in a synergistic effect, markedly improving progression-free survival rates compared to endocrine therapy alone. Benefits and Impact The introduction of Palbociclib has substantially altered the landscape of breast cancer treatment. One of its significant advantages is its ability to provide a non-invasive treatment option that prolongs disease progression, allowing patients to maintain their quality of life. Clinical trials have demonstrated that patients treated with Palbociclib in combination with letrozole experienced a median progression-free survival of over 24 months, a notable improvement compared to patients receiving only letrozole. This has led to its inclusion in treatment guidelines and its adoption as a standard care option in various clinical settings. Side Effects and Management While Palbociclib is generally well-tolerated, like any medical treatment, it can be associated with side effects. Commonly reported adverse events include neutropenia, fatigue, nausea, and alopecia. Neutropenia, a decrease in neutrophils, is the most prevalent side effect. However, this condition is usually manageable with dose adjustments or temporary treatment discontinuation. Healthcare providers typically conduct routine blood tests to ensure patient safety and adjust treatment protocols as necessary. Encouragingly, the incidence of severe infections remains low, highlighting the manageable nature of the drug’s side effects. Patient-Centric Approach The success of Palbociclib also lies in its patient-centric approach, aligning treatment with the preferences and lifestyles of individuals with advanced breast cancer. Its oral administration grants patients greater flexibility and convenience, a distinct advantage over intravenous chemotherapy. This aspect not only improves adherence but also enhances the overall treatment experience, allowing patients to continue their daily activities with minimal disruption. Potential for Future Research The promising results of Palbociclib in HR+, HER2- breast cancer have spurred ongoing investigations into its potential applications in other cancer types. Research is being conducted to explore its efficacy in various settings, such as in combination with other targeted therapies or immunotherapies, as well as its use as an adjuvant treatment. These studies aim to extend the benefits of Palbociclib beyond its current indications, potentially offering new hope for patients with different cancer types. Conclusion In conclusion, Palbociclib represents a significant advancement in targeted cancer therapy, offering a powerful tool against specific breast cancer subtypes. By effectively inhibiting CDK4/6, it disrupts cancer cell proliferation, leading to improved patient outcomes and quality of life. As research continues to unfold, the potential for Palbociclib to be integrated into broader therapeutic strategies remains promising, paving the way for future advancements in cancer treatment. Through its targeted mechanism and favorable safety profile, Palbociclib continues to be a pivotal component in the fight against breast cancer, offering renewed hope to patients worldwide.
Molecular Formula	C24H29N7O2
Molecular Weight	447.5 g/mol
Appearance	White or almost white powder
Quality Standard	Enterprise standard; 98%- 102%(ICP-AES)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28 ℃ for short term (days to weeks) or 8-20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Product Image

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

Company profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Palbociclib

Other Name:

Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-;6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one;6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one;PD 0332991;PD 332991;Palbociclib;6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one;Ibrance;PD 991;Palbocyclib

CAS No.:

571190-30-2

Molecular Formula:

C24H29N7O2

InChIKeys:

InChIKey=AHJRHEGDXFFMBM-UHFFFAOYSA-N

Molecular Weight:

447.54

Exact Mass:

447.53

EC Number:

1592732-453-0

UNII:

G9ZF61LE7G

NCI Thesaurus Code:

C49176

ATC Code:

L01XE33|L - Antineoplastic and immunomodulating agents

Categories:

Antineoplastic Agents

Characteristics

PSA:

103

XLogP3:

1.8

Density:

1.3±0.1 g/cm3

Melting Point:

200 °C

Boiling Point:

711.5°C at 760 mmHg

Flash Point:

384.1±35.7 °C

Refractive Index:

1.648

Water Solubility:

10 mg/ml (isethionate form)

PKA:

7.4(the secondary piperazine nitrogen) and 3.9 (the pyridine nitrogen)

Dissociation Constants:

7.4 (the secondary piperazine nitrogen) and 3.9 (the pyridine nitrogen)

See More Palbociclib Properties 

Hazard Identification

Classification of the substance or mixture

Germ cell mutagenicity, Category 2

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H341 Suspected of causing genetic defects H360 May damage fertility or the unborn child H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Palbociclib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Palbociclib	1.00 KG	May 19, 2026
India	Palbociclib	1.00 KG	May 9, 2026
India	Palbociclib	1 KG	Nov 24, 2025
India	Palbociclib	1.00 KG	Jul 12, 2024
Bangladesh	Palbociclib	1 KG	Jun 5, 2024

Post an enquiry for this product

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