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Best Quality 99% Dexmedetomidine hydrochloride CAS:145108-58-3 From Hyperchem

Name: Best Quality 99% Dexmedetomidine hydrochloride CAS:145108-58-3 From Hyperchem
Brand: HyperChem
SKU: pr2512263021
Price: 26 USD
Availability: InStock

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Unit Price:

$26-30/G FOB

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CAS No.:

1374853-91-4

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1g/bag, 20g/bag, 50g/bags or other quantities

Price valid (until):

2027-04-30

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Dexmedetomidine hydrochloride
CAS number	145108-58-3
Synonym	Dexmedetomidine HCL;
Description	Dexmedetomidine Hydrochloride: An Overview Description: Dexmedetomidine hydrochloride is a highly selective α2-adrenergic receptor agonist used primarily as a sedative and anxiolytic agent in medical settings. The compound is characterized by its ability to provide sedation that somewhat resembles natural sleep, allowing for easily arousable patients who are calm and cooperative. Its chemical structure facilitates the crossing of the blood-brain barrier, enhancing its potency as a central nervous system (CNS) depressant. It is often administered intravenously and is typically used in intensive care settings and for procedural sedation. Mechanism of Action: The primary mechanism of action of dexmedetomidine hydrochloride is its selective agonism at α2-adrenergic receptors in the brain and spinal cord. These receptors are G-protein coupled receptors involved in various physiological processes. When dexmedetomidine binds to these receptors, a neurotransmitter involved in sympathetic nervous system responses. This results in decreased sympathetic tone and a subsequent reduction in blood pressure and heart rate, contributing to its sedative properties. Moreover, dexmedetomidine’s central action helps modulate pain pathways and provides analgesia, making it a valuable agent for pain management without the respiratory depression often associated with opioid medications. Its sedative effects are not reliant on the γ-aminobutyric acid (GABA) system, which differentiates it from other sedatives. This unique mode of action contributes to its ability to provide sedation without significant respiratory depression, making it particularly useful in various clinical settings. Usage: Dexmedetomidine hydrochloride is primarily used for sedation in critically ill or mechanically ventilated patients in intensive care units (ICUs). It is also employed in non-intubated patients requiring mild to moderate sedation prior to and/or during surgical and other procedures. Its use extends to sedation in both adult and pediatric patients and has become a vital component in procedural sedation due to its favorable pharmacokinetic and pharmacodynamic profiles. The drug is appreciated for its anxiolytic and analgesic-sparing effects, reducing the need for additional analgesics or sedatives. For instance, in surgical settings, dexmedetomidine can be used as part of an anesthesia regimen to enhance patient comfort and reduce stress responses to surgical stimuli. It is especially beneficial in procedures requiring patient cooperation or when rapid recovery of cognitive function is desired post-procedure. Chemical Classification: Dexmedetomidine hydrochloride falls under the chemical classification of imidazole derivatives. Its molecular formula is C13H16N2 · HCl, and it is typically provided as a sterile, preservative-free solution for intravenous infusion. Its highly lipophilic nature allows for rapid central nervous system penetration and onset of action, making it a superior choice for quick sedation needs. Other Aspects: Dexmedetomidine hydrochloride is esteemed for its safety and efficacy profile, although it must be used under strict medical supervision due to potential side effects, such as bradycardia, hypotension, and dry mouth. The sedation it provides is dose-dependent, and customizable to meet the individual needs of the patient, allowing for an adaptable approach to sedative care. Patients receiving dexmedetomidine tend to have a more stable cardiovascular profile compared to those sedated with alternative agents; however, healthcare providers must stay vigilant for any hemodynamic changes that may arise. Its sparing effect on opioids and other analgesics is another advantageous feature, as minimizing opioid use can reduce the risk of dependency and other side effects. Dexmedetomidine also exhibits neuroprotective properties due to its ability to decrease oxidative stress and inflammation in the CNS. This aspect of the drug is currently under investigation for potential protective roles in various neurological disorders and for its application in enhancing outcomes following neurological surgery or injury. In conclusion, dexmedetomidine hydrochloride is a versatile and effective sedative with a unique mechanism of action that offers numerous clinical benefits, particularly in the field of critical care and procedural sedation. Its ability to provide sedation without significant respiratory depression, combined with its analgesic-sparing properties, makes it a valuable tool in modern anesthetic and sedation practices. As research continues to explore its broader applications, dexmedetomidine is likely to maintain its pivotal role in medical sedation.
Structure
Molecular Formula	C ₁₃ H ₁₇ ClN ₂
Molecular Weight	236.74 g/mol
Appearance	White or almost white crystalline powder
Quality Standard	USP EP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Pembrolizumab (brand name Keytruda) is a PD-1 inhibitor developed by Merck & Co., Ltd. It was first approved by the FDA in 2014 for the treatment of certain patients with metastatic melanoma. In 2015, the FDA approved Keytruda (pembrolizumab) for advanced non-small cell lung cancer. Subsequently, pembrolizumab was approved for the treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma, as first-line treatment for certain metastatic non-small cell lung cancer patients, Hodgkin's lymphoma (cHL), and certain locally advanced or metastatic urothelial carcinoma patients. In 2025, the FDA approved pembrolizumab as neoadjuvant therapy for PD-L1+ resectable locally advanced head and neck squamous cell carcinoma, and continued as adjuvant therapy in combination with radiotherapy.

Certificates

Basic Info

Product Name:

Pembrolizumab

Other Name:

Pembrolizumab;Pembrolizumab (anti-PD-1);PEMBROLIMUMAB PD-1 1374853-91-4;Pembrolizumab 25mg/ml;PembrolizumabQ: What is Pembrolizumab Q: What is the CAS Number of Pembrolizumab Q: What is the storage condition of Pembrolizumab Q: What are the applications of Pembrolizumab;Research Grade Pembrolizumab(DHH02202);MK-3475;Research Grade Pembrolizumab

CAS No.:

1374853-91-4

Molecular Weight:

EC Number:

807-012-2

Color/Form:

Colorless to light yellow

Categories:

Blood System Drugs

Characteristics

Critical Temperature & Pressure:

Store at -80°C

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Netherlands	High quality Pembrolimumab/ supplier with competitive price in stock-Rechems Cas No: 1374853-91-4	1 KG	Jan 2, 2025
Netherlands	pembrolizumab	1 KG	Jan 2, 2025
South Korea	pembrolizumab	10 G	Nov 28, 2024

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Best Quality 99% Dexmedetomidine hydrochloride CAS:145108-58-3 From Hyperchem

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