ARA290 99% Raw Lyophilized Powder Cibinetide Acetate Ara-290 Peptide Neuroprotective Vial Peptide Bulk Price

Cibinetide (ARA290) is a synthetic, nonerythropoietic 11-mer peptide engineered from the helix B surface domain of erythropoietin (EPO). It retains EPO's tissue-protective and anti-inflammatory properties but lacks hematopoietic activity, making it ideal for neuroprotective and immunomodulatory research 147.

Mechanism of Action

ARA290 selectively activates the innate repair receptor (IRR), a heterodimer of the EPO receptor and CD131 (β-common receptor). This receptor is upregulated in injured tissues and triggers:

• Anti-inflammatory responses: Inhibits apoptosis and cell death signals.

• Neuroprotection: Modulates pain signaling via immune-nociception integration, particularly through TRPV1 channel targeting.

• Tissue regeneration: Enhances endothelial cell proliferation and migration

• Key Research Applications

  1. Neuropathic Pain Relief:

     • Provides long-term analgesia by suppressing spinal microglia activation and reducing neuroinflammation in peripheral nerve injury models 18.

  2. Diabetes & Autoimmune Disorders:

     • Improves glucose tolerance in diabetic models and attenuates experimental autoimmune encephalomyelitis (EAE) severity 78.

  3. Organ Protection:

     • Shields kidneys from cisplatin-induced toxicity and enhances human islet survival in transplantation stress 812.

  4. Vascular Repair:

     • Boosts blood flow recovery in ischemic tissues by promoting endothelial colony-forming cell (ECFC) activity 712.

ARA290 (Cibinetide) Product Overview

Product Identification

• CAS Number: 1208243-50-8

• Synonyms: ARA-290, pHBSP (Pyroglutamate Helix B Surface Peptide)

• Molecular Formula: C₅₁H₈₄N₁₆O₂₁

• Molecular Weight: 1257.3 g/mol

• Sequence: Pyroglutamic acid-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyr-EQLERALNSS-OH) 145.

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