Fostamatinib RC10522
3 Inquiries
901119-35-5
Pharmaceutical Grade
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceFostamatinib (R788), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018 under the trade name Tavalisse for use in ITP. Fostamatinib has also been granted orphan drug status by the FDA.|Fostamatinib is an orally available small molecule inhibitor of spleen tyrosine kinase that is used to treat chronic immune thrombocytopenia. Fostamatinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy but has yet to be linked to instances of clinically apparent acute liver injury.|Fostamatinib is a small molecule Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.Basic Info-
Product Name:
Fostamatinib
Other Name:2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one,6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one;Fostamatinib;R 788;945745-48-2
CAS No.:901119-35-5
Molecular Formula:C23H26FN6O9P
InChIKeys:InChIKey=GKDRMWXFWHEQQT-UHFFFAOYSA-N
Molecular Weight:580.4595042
Exact Mass:580.46
EC Number:1533716-785-6
UNII:SQ8A3S5101
NCI Thesaurus Code:C95222
ATC Code:B02BX|B - Blood and blood forming organs
Categories:
Characteristics-
PSA:
187
XLogP3:2.12
Density:1.5±0.1 g/cm3
Boiling Point:814.2±75.0 °C at 760 mmHg
Flash Point:446.2±37.1 °C
Refractive Index:1.629
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Fostamatinib
1 KG May 16, 2025 
India
fostamitinib
1 G Jun 11, 2026
India
Fostamatinib
20 MG Jun 1, 2026 Post an enquiry for this product
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