High purity Humanin

Name:  Lynn
Wechat：  15914422644

Tel：+86  15914422644

Whatsapp: +852 6252 8290

Email：    guangsheng 5   @zgguangsheng.com

1. Core Molecular & Physicochemical Properties

1. Receptor-Mediated Signaling
   Humanin binds to a heterotrimeric receptor complex consisting of CNTFR, WSX-1, and gp130, activating downstream pathways including JAK2/STAT3, PI3K/Akt, and MAPK/ERK. This signaling cascade suppresses the release of pro-inflammatory cytokines (TNF-α, IL-1β) and inhibits apoptotic pathways.
2. Direct Anti-Apoptotic Activity
   It interacts with the pro-apoptotic protein Bax, preventing Bax translocation to the mitochondrial membrane, reducing cytochrome C release, and blocking the caspase-dependent apoptotic cascade, thus protecting neurons, cardiomyocytes, and islet cells from stress-induced death.
3. Mitochondrial Function Regulation
   Humanin enhances mitochondrial biogenesis and metabolic efficiency, reduces reactive oxygen species (ROS) accumulation, and improves cellular energy supply, which is critical for mitigating mitochondrial dysfunction associated with aging and metabolic disorders.
4. Secretory & Paracrine Action
   Lacking a classical signal peptide, Humanin can still be secreted by cells and exert paracrine/autocrine effects, mediating intercellular communication in tissues such as the brain, heart, and liver.

3. Key Biological Activities & Research Applications

Core Biological Activities

• Neuroprotection: Inhibits amyloid-β (Aβ)-induced neuronal apoptosis, alleviates neurotoxicity associated with Alzheimer’s disease (AD), promotes nerve regeneration, and provides protective effects against stroke and traumatic brain injury (TBI).
• Cytoprotection: Safeguards cardiomyocytes, renal tubular cells, and pancreatic islet cells against ischemia-reperfusion injury, oxidative stress, and toxin-induced damage.
• Metabolic Regulation: Improves insulin sensitivity, lowers blood glucose levels, enhances glucose tolerance, and holds potential for research on type 2 diabetes mellitus (T2DM) and metabolic syndrome.
• Anti-Inflammatory & Immunomodulation: Suppresses pro-inflammatory signaling pathways, reducing chronic inflammation and alleviating pathological damage in autoimmune diseases.

Major Research Application Areas

• Safety Profile: Native Humanin has low immunogenicity, with only mild injection-site reactions reported in preclinical studies. No significant hematological, hepatic, or renal toxicity has been observed, and it shows no cross-reactivity with erythropoietin (EPO)-class peptides.
• Research-Only Notice: Restricted to laboratory research use; not approved for clinical therapeutic applications in humans.
• Handling Tips: Reconstitute with sterile, pyrogen-free water or PBS; avoid vigorous shaking during dissolution. Engineered analogs (e.g., HNG) offer superior experimental reproducibility and stability compared to native Humanin.