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High Purity KLOW

Name: High Purity KLOW
Brand: Guangsheng
SKU: pr2601161237
Price: 265 USD
Availability: InStock

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Unit Price:

$265/UNIT FOB

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CAS No.:

49557-75-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Guangzhou

Brand:

Guangsheng

Packaging:

80mg*10vials

Price valid (until):

2030-12-19

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Guangsheng Technology co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

beaty prodt

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Name: Lynn
Wechat： 15914422644

Tel：+86 15914422644

Whatsapp: +852 6252 8290

Email： guangsheng 5 @zgguangsheng.com

1. Core Composition & Physicochemical Specifications

Item	Details
Blend Components	GHK - Cu (50 mg)+BPC - 157 (10 mg)+TB - 500 (10 mg)+KPV (10 mg); total 80 mg
Individual Peptide Purity	≥98% (HPLC); blend overall purity ≥99%
Formulation	White lyophilized powder; reconstituted with bacteriostatic water/PBS
Solubility	Soluble in water (≥20 mg/mL) after reconstitution; pH 6.0 - 7.4 optimal
Stability	Stable at - 20°C for 2 - 3 years (sealed, light - protected); reconstituted solution stable at 2 - 8°C for 1 month
Key Quality Metrics	Endotoxin ≤0.1 EU/mg; moisture ≤0.5%; heavy metals ≤10 ppm

2. Mechanism of Action (Synergistic Effects)

The blend's efficacy stems from the complementary actions of its four components:

GHK - Cu: Stimulates collagen synthesis, enhances antioxidant defense, and promotes skin/tissue remodeling; acts as a copper - dependent signaling molecule to regulate gene expression related to tissue repair.
BPC - 157: Accelerates angiogenesis, boosts fibroblast migration, and strengthens tissue integrity; protects against gastrointestinal and musculoskeletal damage by modulating growth factor signaling.
TB - 500: Facilitates cell migration and actin polymerization, reduces fibrosis, and accelerates the healing of tendons, muscles, and other soft tissues.
KPV: Blocks CXCR2, inhibits NF - κB/MAPK pathways to reduce inflammation, and supports wound closure by promoting keratinocyte migration without excessive scarring.
Synergy: GHK - Cu/KPV addresses inflammation and collagen production; BPC - 157/TB - 500 enhances repair and angiogenesis, creating a comprehensive regenerative environment.

3. Biological Functions & Application Fields

3.1 Core Physiological Effects

Skin Regeneration: Improves skin elasticity, reduces wrinkles, and accelerates wound healing by promoting collagen/elastin synthesis and reducing inflammation.
Soft Tissue Repair: Enhances healing of muscles, tendons, and ligaments; reduces post - injury fibrosis and scarring.
Anti - Inflammatory: Inhibits pro - inflammatory cytokine release (TNF - α, IL - 6), alleviating localized and systemic inflammation.
Gastrointestinal Protection: BPC - 157 component supports gut barrier function and heals mucosal lesions.

3.2 Application Fields

Field	Usage Scenarios
Preclinical Research	Studying tissue regeneration, wound healing, and inflammatory pathways in rodent models.
Skin Research	Evaluating anti - aging, wound - care, and post - inflammatory hyperpigmentation treatments.
Musculoskeletal Research	Investigating soft - tissue injury repair and fibrosis reduction strategies.
Topical Formulation Development	Developing transdermal blends for localized tissue repair studies.

4. Production & Quality Control

4.1 Manufacturing Processes

Individual Peptide Synthesis: Each peptide (GHK - Cu, BPC - 157, TB - 500, KPV) is synthesized via SPPS (Fmoc chemistry) and purified by RP - HPLC to ≥98% purity.
Blending & Lyophilization: Components are mixed in precise ratios, lyophilized to form a stable powder, and vacuum - sealed with desiccant.
Quality Validation: Each batch undergoes identity (mass spectrometry), purity (HPLC), endotoxin (LAL), and moisture (Karl Fischer) testing before release.

4.2 Quality Testing Standards

Test Item	Specification	Detection Method
Purity (Individual Peptides)	≥98%	RP - HPLC (C18 column, gradient elution)
Identity	Matches reference standards	Mass spectrometry, amino acid analysis
Endotoxin	≤0.1 EU/mg	Limulus Amebocyte Lysate (LAL) test
Moisture	≤0.5%	Karl Fischer titration
Heavy Metals	≤10 ppm	ICP - MS

5. Administration, Safety & Regulatory Status

5.1 Administration Routes & Dosage

Preclinical Injection: Subcutaneous (SC) injection (0.2 mL reconstituted solution, 20 - 50 μg/kg, 5 times/week for 3 weeks); intraperitoneal (IP) injection (1 - 5 mg/kg/day).
Topical Use: 0.5% - 1% blend in cream/serum, applied twice daily for localized studies.
Cell Culture: 1 - 10 μM for in vitro studies on cell migration and inflammation.

5.2 Safety Profile

Low Toxicity: No systemic toxicity reported in rodent studies; individual components have LD₅₀ > 100 mg/kg.
Minimal Side Effects: Transient local irritation at injection sites; no off - target organ damage observed.
Contraindications: Hypersensitivity to any peptide component; avoid use in pregnant/lactating animals (limited data).
Research Use Only: Not approved for human clinical use; for laboratory research applications only.

5.3 Handling Guidelines

Storage: Store lyophilized powder at - 20°C; reconstituted solution at 2 - 8°C for up to 1 month.
Reconstitution: Use bacteriostatic water; avoid repeated freeze - thaw cycles to prevent peptide degradation.
Transport: Cold chain transportation (2 - 8°C) to maintain stability.

6. Key Advantages & Limitations

6.1 Advantages

Synergistic Efficacy: Combines four peptides to address regeneration, inflammation, and repair simultaneously, outperforming single - peptide treatments.
Multi - Tissue Application: Suitable for skin, musculoskeletal, and gastrointestinal research, offering broad utility.
Cost - Effective: Pre - blended format reduces synthesis and testing costs for research labs.
Well - Characterized: Each component has extensive preclinical data, supporting mechanism - of - action studies.

6.2 Limitations

pH Compatibility Issues: GHK - Cu (optimal pH 5.5 - 6.5) and TB - 500/KPV (optimal pH 7.0 - 7.4) may have stability conflicts in a single formulation.
Short Half - Life: Rapid in vivo clearance requires frequent dosing or sustained - release formulations.
Preclinical Only: Limited human data; clinical translation requires further safety and efficacy studies.

About Us

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Product Detail

1. Molecular & Physical Properties

Amino Acid Sequence: Ala-His-Lys-Cu, formed by chelating the tripeptide alanyl-histidyl-lysine with copper ions.
Purity: ≥99% (HPLC verified), ensuring high bioactivity and minimal impurities.
Physical Appearance: Deep blue lyophilized powder, highly water-soluble for easy formulation into solutions, creams, or injectables.
Stability: Optimal storage at -20℃; stable for 24 months when sealed from light and moisture; avoid high temperatures to prevent copper ion dissociation.

2. Core Biological Mechanisms

Collagen & Elastin Synthesis: It upregulates the expression of TGF-β and matrix metalloproteinase inhibitors (TIMPs), stimulating fibroblasts to produce type I/III collagen and elastin. This enhances skin elasticity, reduces fine lines, and improves skin texture.
Antioxidant & Anti-inflammatory Effects: The copper ion moiety scavenges free radicals (e.g., superoxide anion, hydroxyl radicals) to mitigate oxidative stress. It also inhibits NF-κB pathways, reducing the release of pro-inflammatory cytokines (TNF-α, IL-6) and alleviating tissue inflammation.
Hair Follicle Activation: It extends the anagen (growth) phase of hair follicles, increases dermal papilla cell proliferation, and improves microcirculation around hair follicles, which aids in reversing hair miniaturization associated with androgenetic alopecia.
Wound Healing Acceleration: By promoting angiogenesis and fibroblast migration, it speeds up granulation tissue formation and epithelialization, shortening recovery time for acute and chronic wounds (e.g., burns, diabetic ulcers).

3. Application Scenarios

Dermatological Cosmetics: Added to anti-aging serums, creams, and masks to improve skin firmness, fade wrinkles, and repair photodamaged skin.
Trichological Research: Used in topical formulations or scalp injections for androgenetic alopecia treatment and hair regrowth studies.
Regenerative Medicine: Applied in wound care dressings and tissue engineering scaffolds to enhance skin and soft tissue repair.
Laboratory Research: Serves as a tool compound for studying copper peptide biology, oxidative stress, and tissue regeneration mechanisms.

4. Safety & Advantages

Non-immunogenic, with no reported allergic reactions or systemic side effects in topical use.
Biodegradable, breaking down into natural amino acids and copper ions that are metabolized by the body.
Compatible with most cosmetic and pharmaceutical excipients (e.g., hyaluronic acid, glycerin), suitable for multi-component formulations.

Product Detail

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ECHEMI Editorial Reference

Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine.
ChEBI: Gly-His-Lys is a tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence. It has a role as a metabolite, a chelator, a vulnerary and a hepatoprotective agent.

Research & Reference Note

High Purity KLOW is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Authoritative sources

Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

Certificates

Basic Info

Product Name:

Copper Peptide

Other Name:

GHK Cu Copper Peptide;L-Lysine,glycyl-L-histidyl-;Copper Peptide powder (GHK-cu);GHK Cu Copper Peptide GHK.Cu GHK-Cu;Liver Cell Growth Factor(GHK);GHKcu/Growth-Modulating peptide;(Gly-His-Lys)2Cu.xHAc;AHK-Cu (Copper Peptide)

CAS No.:

49557-75-7

Molecular Formula:

C14H24N6O4

InChIKeys:

MVORZMQFXBLMHM-QWRGUYRKSA-N

Molecular Weight:

340.38

EC Number:

1592732-453-0

Color/Form:

Off-White

Categories:

Other Chemical Drugs

Characteristics

Density:

1.324

Melting Point:

>144°C (dec.)

Boiling Point:

831.0±65.0 °C(Predicted)

PKA:

3.11±0.10(Predicted)

Critical Temperature & Pressure:

under inert gas (nitrogen or Argon) at 2–8 °C

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Copper Peptide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
beaty prodt

Location:
Yongtai Jinli City Plaza, Baiyun District, Guangzhou City, Guangdong Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
30

Total Annual Revenue:
Less than $1 million

Total Employees:
5-10

Year of Establishment:
2023

Inquiry History

150 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Cosmetic Copper GhkCU Peptide CAS 49557-75-7 Peptide 50mg Ghk-Cu	2 MT	Nov 6, 2023
Malaysia	High quality 98% up Copper Peptide GHK-Cu powder CAS 49557-75-7	1 KG	Oct 19, 2023
United States	Copper Peptide 99% Copper Peptide Ghk-Cu Powder Ghk Cu CAS 49557-75-7	1 KG	Mar 26, 2026
Sweden	GHK-Cu	1 KG	Mar 17, 2026
China	Glycyl-l-histidyl-l-lysine	10 KG	Oct 24, 2023
Germany	GHK CU	100 MG	Aug 12, 2026
Australia	Copper peptide	1 MT	Aug 10, 2026
Russia	GHK-Cu	50 MG	Aug 6, 2026
United States	copper-peptide ghk-cu	20 MT	Jul 26, 2026
Peru	GHK-Cu	15 MG	Jul 13, 2026
United States	GHK-Cu	100 MG	Jul 13, 2026
United States	GHK-Cu	1 G	Jul 13, 2026
United States	GHK-CU	5 MT	Jul 12, 2026
Malaysia	GHK-Cu	1 G	Jul 9, 2026
South Africa	GHK-CU	3 MG	Jun 17, 2026
United States	GHK-CU	1 MT	Jun 13, 2026
United Kingdom	GHK-CU	5 KG	Jun 11, 2026
Canada	Ghk-cu	500 MG	Jun 11, 2026
Australia	GHK-Cu	1 G	Jun 8, 2026
Thailand	GHK-CU	100 MG	Jun 5, 2026

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High Purity KLOW

Product Description

Seller Information

Inquiry History

1. Core Composition & Physicochemical Specifications

2. Mechanism of Action (Synergistic Effects)

3. Biological Functions & Application Fields

3.1 Core Physiological Effects

3.2 Application Fields

4. Production & Quality Control

4.1 Manufacturing Processes

4.2 Quality Testing Standards

5. Administration, Safety & Regulatory Status

5.1 Administration Routes & Dosage

5.2 Safety Profile

5.3 Handling Guidelines

6. Key Advantages & Limitations

6.1 Advantages

6.2 Limitations

1. Molecular & Physical Properties

2. Core Biological Mechanisms

3. Application Scenarios

4. Safety & Advantages

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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