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99% pure high quality raw material macitentan CAS 441798-33-0 with Best Price

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Unit Price: Get Latest Price 

CAS No.:

441798-33-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Packaging:

1kg/bag;25kg/Cardboard Drum

Sample Available:

Yes

Price valid (until):

2026-03-03

Contact Supplier

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Xi'an Honest BioEngr Co.,Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,100% TT in advance

Average Lead Time:

30 days

Qualification:

Main Products:

Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10

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Product Details
Seller Information
Inquiry History

Description

Product Detail

Superiority

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address

1.High quality and competitive price.
2.Free sample for your evaluation.
3.Promptly delivery by well-reputed shipping lines.
4.Trial order is available for testing after samples.
5.We will inform you all the information at every stage in advance.
6.Packaging can gear to buyers' special request.

Our service

1. Reply your inquiry in 24 working hours.
2. Customized design is available. OEM are welcomed.
3. Exclusive and unique solution can be provided to our customer by our well-trained and professional engineers and
staff.
4. Professional factory: We are manufacturer, specializing in producing all kinds of herb extract for more than 10 years, competitive with good quantity.
5. As an honest seller, we always use superior raw material, advanced machines, skilled technicians to ensure our products to be finished in high quality and stable feature.

FAQ

1.: Are you a factory or trading company
We are the integration of factory and trade.

2.: How is the quality I want to test.
Before production and extraction, we will test all raw materials.Quality is our top priority.All products are strictly tested and confirmed by our QC and QA, approved by Third Party Lab in China.So you will be assured with Good Quality if you choose us. We welcome you test the product and hope to get your feedback.

3.: Can I get a Free sample
Yes,We can provide free samples.For most products we can provide you a free sample, You only need to pay for Shipping. Plesae be free to consult our salesman.
For a larger quantity, we always support you with better price, and we will have some discount in some especial days.

4. : What's your main payment method
T/T (Bank transfer), Wechat,Alipay,Credit card payment.

5. : Have you received my payment How long will it take
Generally, we can receive your payment the next day, and we will inform you as soon as we receive your payment.
After confirmation payment, we will send out package

6.:When will you sent out the goods after successful payment
Normally the order will be delivery within 1-3 days after the order confirmed, except the customized products.

7.:What modes of transportation do you have to choose
We cooperate with HKEMS, DHL, TNT, UPS, FEDEX, EMS, China Air Post ,sea transportation etc.
And with the SAFE SHIPPING in each country, you can receive the goods smoothly.It is fast and safe method.

8.:How long does it take to the goods arrived
It is Depending on your location:
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, HKEMS,Netherlands post.
For large order, please allow 5-8 days by Air, 20-35 days by Sea
At the same time, we have warehouses in Germany and California, and some orders can be sent directly from Germany or California.

9.:How is the goods packed
We usually send goods with disguise package outside and a double-layer sterile transparent bag inside.We have tried thousand of package methods, it looks serious and discreet.

10.: How can I get a discount
Our products have already given you a discount, and the price is favorable. Orders above $1,000 can enjoy 95% discount, transportation discount or additional sample products. Therefore, for larger quantities, we always support better prices.

11.: How to proceed order
Please Let me konw the product you are looking for,quantity and the destination country wihch help me to give you a right price;
After you confirm all details of order, pay money in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.

12.:When will I receive the shipping number Where I can check status of my order
After the goods are sent out, our staff will send you the shipping number via email, online or WhatsApp ASAP.You can also check the status online on 17track.

13.:Is a signature required for the shipping?
Our shipping method requires no signature from your side upon delivery.

ECHEMI Editorial Reference

Macitentan is an orally active, non-peptide endothelin receptor antagonist for the treatment of idiopathic pulmonary fibrosis and pulmonary arterial hypertension.
Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an endothelin receptor antagonist, an antihypertensive agent and an orphan drug. It is an organobromine compound, a member of pyrimidines, an aromatic ether, a ring assembly and a member of sulfamides. It derives from an ethylene glycol and an ACT-132577.|Macitentan was approved in October 2013. It is indicated for patients with pulmonary arterial hypertension, and is marketed under the brand name Opsumit. Macitentan is an antagonist/blocker of endothelin receptors on blood vessels and smooth muscle, and, thus, blocks the stimulation of vasculature hypertrophy, inflammation, fibrosis, proliferation, and vasoconstriction. Similar to all drugs acting on the renin-angiotensin system, macitentan is associated with embryo and fetal toxicity, so it should not be used in pregnancy and has special precautions that must be followed for all females of child-bearing age.|Macitentan is an Endothelin Receptor Antagonist. The mechanism of action of macitentan is as an Endothelin Receptor Antagonist.|Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). Macitentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.|Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.

Basic Info

Product Name:

Macitentan

Other Name:

Sulfamide,N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propyl-;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propylsulfamide;Macitentan;ACT 064992;Propylsulfamic acid N-[5-(4-bromophenyl)-6-[2-[(5-bromopyrimidin-2-yl)oxy]ethoxy]pyrimidin-4-yl]amide;Opsumit

CAS No.:

441798-33-0

Molecular Formula:

C19H20Br2N6O4S

InChIKeys:

InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N

Molecular Weight:

590.295

Exact Mass:

588.27

EC Number:

1308068-626-2

UNII:

Z9K9Y9WMVL

DSSTox ID:

DTXSID50196063

NCI Thesaurus Code:

C87728

ATC Code:

C02KX04|C - Cardiovascular system

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

137

XLogP3:

3.7

Density:

1.675

Boiling Point:

692.397°C at 760 mmHg

Flash Point:

372.5±34.3 °C

Refractive Index:

1.634

Water Solubility:

Not water soluble

See More Macitentan Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Macitentan Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10

Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA

Payment Terms:
TT against copy of documents,100% TT in advance

Average lead Time:
30 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2023

Company Profile

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Purity 99% Chemical Drugs Quetiapine CAS 111974-69-7	500 G	Oct 31, 2023

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99% pure high quality raw material macitentan CAS 441798-33-0 with Best Price

Product Details

Seller Information