*Product Photos

Product Introduction

1. Product Overview

2. Mechanism of Action & Functional Activity

2.1 Antibacterial Mechanism

2.2 Antibacterial Activity

• Susceptible Bacteria: It exhibits strong activity against Enterobacteriaceae (Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., etc.), with MIC₉₀ values mostly ranging from 0.03 to 0.5μg/ml; it has extremely low MIC₉₀ values (0.015-0.06μg/ml) against Haemophilus influenzae (including β-lactamase-producing strains) and Neisseria meningitidis; for Gram-positive cocci such as Streptococcus pneumoniae and Streptococcus pyogenes, the MIC₉₀ values are 0.015-0.12μg/ml.
• Weakly Active/Resistant Bacteria: It shows moderate activity against methicillin-susceptible Staphylococcus aureus (MIC₉₀=1-4μg/ml), no antibacterial activity against Pseudomonas aeruginosa and Alcaligenes spp., and complete resistance to methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus spp.

3. Clinical Significance & Applications

3.1 Clinical Value

3.2 Main Application Areas

• Respiratory Tract Infections: Treatment of community-acquired pneumonia, hospital-acquired pneumonia, lung abscess, bronchiectasis with infection, etc., especially suitable for critically ill patients with concurrent sepsis or respiratory failure.
• Central Nervous System Infections: Treatment of bacterial meningitis caused by Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, Escherichia coli, etc., and it is one of the first-choice drugs for pediatric meningitis.
• Urinary Tract Infections: Used for acute pyelonephritis, complicated urinary tract infections (such as those associated with urinary tract obstruction or catheter-related infections). The drug has high concentration in kidney tissue and can effectively eliminate pathogenic bacteria in lesions.
• Sepsis & Bloodstream Infections: As a core drug for the treatment of sepsis caused by Gram-positive and negative bacteria, it can quickly control bacterial proliferation in the bloodstream and reduce the risk of septic shock.
• Abdominal & Pelvic Infections: Used for peritonitis, cholangitis, cholecystitis, intra-abdominal abscess, pelvic inflammatory disease, endometritis, etc., often combined with anti-anaerobic drugs such as metronidazole.
• Skin & Soft Tissue Infections: Treatment of cellulitis, erysipelas, wound infections, burn infections, etc., which can effectively control local inflammation and prevent infection from spreading to deep tissues.
• Bone & Joint Infections: Used for osteomyelitis and suppurative arthritis. The drug can penetrate bone tissue and synovial fluid to reach effective antibacterial concentration.

4. Storage & Handling

4.1 Storage Conditions

• Temperature: Should be stored in a refrigerated environment at 2-8℃, avoiding exposure to high temperatures above 30℃. High temperatures will accelerate the hydrolysis of the β-lactam ring and lead to a decrease in drug potency.
• Humidity: The relative humidity of the storage environment should be controlled at 30%-60% to prevent the product from absorbing moisture and caking, which may affect solubility and stability.
• Light Protection: Use opaque packaging containers (such as aluminum foil composite bags, amber glass bottles) to avoid photodegradation reactions caused by ultraviolet radiation.
• Atmosphere: It is recommended to store under the protection of inert gases to reduce the oxidation of the drug by oxygen in the air.

4.2 Packaging Specifications

4.3 Shelf Life & Handling Precautions

• Shelf Life: Under the recommended sealed, refrigerated and light-protected storage conditions, the shelf life is 24 months from the date of manufacture. The potency of expired products may decrease significantly, and the content of related impurities may exceed the limit, so they are strictly prohibited from use.
• Handling Precautions: The product should be used within 24 hours after opening the package. If not used immediately, it should be resealed tightly and stored in a refrigerator for a maximum of 72 hours. During transportation, refrigerated trucks or insulated containers with ice packs should be used to maintain the temperature at 2-8℃, avoiding violent shock, collision, exposure to sunlight and rain. Unused or expired products and packaging materials are classified as pharmaceutical waste, which should be handled by professional institutions in accordance with local environmental protection regulations to avoid environmental pollution.