Tolbutamide RC02393
64-77-7
Pharmaceutical Grade
99%
Royalchem
25kg/drum
2029-12-31
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceTolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.Target: Potassium ChannelTolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Tolbutamide act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Tolbutamide belongs to a class of medications called sulfonylureas. Tolbutamide inhi
Tolbutamide appears as white crystals. (NTP, 1992)|Solid
Tolbutamide appears as white crystals. (NTP, 1992)|Tolbutamide is an N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position. It has a role as a hypoglycemic agent, a potassium channel blocker, a human metabolite and an insulin secretagogue.|Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces.|Tolbutamide is a Sulfonylurea.|Tolbutamide is a short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to cause adverse effects, such as jaundice. This agent is rapidly metabolized by CYPC29.|A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)Basic Info-
Product Name:
Tolbutamide
Other Name:Benzenesulfonamide,N-[(butylamino)carbonyl]-4-methyl-;Urea,1-butyl-3-(p-tolylsulfonyl)-;N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide;D 860;Artosin;Butamide;1-Butyl-3-(p-methylphenylsulfonyl)urea;N-Butyl-N′-p-toluenesulfonylurea;1-Butyl-3-(p-tolylsulfonyl)urea;N-n-Butyl-N′-tosylurea;Diaben;Diabuton;Dolipol;Ipoglicone;Mobenol;Orabet;Oralin;Orinase;Rastinon;N-(Sulfonyl-p-methylbenzene)-N′-n-butylurea;Tolbutamide;Toluina;N-(p-Tolylsulfonyl)-N′-butylcarbamide;3-(p-Tolyl-4-sulfonyl)-1-butylurea;Diabetol;Butamid;N-(4-Methylphenylsulfonyl)-N′-butylurea;N-(4-Methylbenzenesulfonyl)-N′-butylurea;Tolbutamid;N-Butyl-N′-(p-tolylsulfonyl)urea;N-Butyl-N′-(4-methylphenylsulfonyl)urea;Aglicid;Arkozal;Artozin;Diabetamid;Orezan;Orinaz;Tolumid;Toluvan;Oterben;Tolbusal;Willbutamide;HLS 831;N-(p-Methylbenzenesulfonyl)-N′-butylurea;Tolumide;Pramidex;Diasulfon;Glyconon;U 2043;NSC 23813;NSC 87833;1-Butyl-3-(4-methylphenyl)sulfonylurea;3-Butyl-1-(4-methylbenzenesulfonyl)urea;100735-34-0
CAS No.:64-77-7
Molecular Formula:C12H18N2O3S
InChIKeys:InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N
Molecular Weight:270.35
Exact Mass:270.35
BRN:1984428
EC Number:200-594-3
UNII:982XCM1FOI
NSC Number:757354|23813
DSSTox ID:DTXSID8021359
NCI Thesaurus Code:C66610
Color/Form:WHITE OR PRACTICALLY WHITE CRYSTALLINE POWDER|Crystals
ATC Code:A - Alimentary tract and metabolism|V - Various
HScode:2935009090
Categories:
Characteristics-
PSA:
83.6
XLogP3:2.3
Appearance:Tolbutamide appears as white crystals. (NTP, 1992)
Density:1.245 g/cm3 @ Temp: 25 °C
Melting Point:128.5-129.5 °C
Flash Point:213.9±26.8 °C
Refractive Index:1.557
Water Solubility:soluble in chloroform.
Storage Conditions:Refrigerator
Toxicity:Oral-rat LD50: 2490 mg/kg; Oral-Mouse LD50: 490 mg/kg
Flammability characteristics:Thermal decomposition emits toxic nitrogen oxides and sulfur oxide fumes
PKA:5.16None
Dissociation Constants:5.16|pKa= 5.16
Collision Cross Section:163 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|161.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:PRACTICALLY ODORLESS; HAS SLIGHTLY BITTER TASTE /SODIUM SALT/
Air and Water Reactions:Insoluble in water.
Reactive Group:Amides and Imides
Reactivity Profile:TOLBUTAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). This chemical is incompatible with acids. (NTP, 1992).
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H317 May cause an allergic skin reaction
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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