Tamibarotene RC11110
1 Inquiries
94497-51-5
Pharmaceutical Grade
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceTamibarotene is a retinoic acid receptor α/β (RARα/β) agonist, showing high selectivity over RARγ.
Solid
Tamibarotene is a dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine. It has a role as an antineoplastic agent and a retinoic acid receptor alpha/beta agonist. It is a member of tetralins, a retinoid and a dicarboxylic acid monoamide. It derives from a 4-carbamoylbenzoic acid and a terephthalic acid.|Tamibarotene is a novel synthetic retinoid for acute promyelocytic leukaemia (APL). Tamibarotene is currently approved in Japan for treatment of recurrent APL, and is undergoing clinical trials in the United States.|Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA. In addition, this agent may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium.Basic Info-
Product Name:
Tamibarotene
Other Name:Benzoic acid,4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-;4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid;Am 80;Tamibarotene;Am 80 (pharmaceutical);NSC 608000;Retinoid AM 80;Amnolake;4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid;RR 110;SY 1425;Am 80 (RAR agonist);INNO 507;TM 441;TOS 80T;OP 01
CAS No.:94497-51-5
Molecular Formula:C22H25NO3
InChIKeys:InChIKey=MUTNCGKQJGXKEM-UHFFFAOYSA-N
Molecular Weight:351.44
Exact Mass:351.44
EC Number:1806241-263-5
UNII:08V52GZ3H9
NSC Number:608000
DSSTox ID:DTXSID5046853
NCI Thesaurus Code:C71025
HScode:2924299090
Categories:
Characteristics-
PSA:
66.4
XLogP3:5.4
Appearance:white to off-white
Density:1.2±0.1 g/cm3
Melting Point:231-232 °C @ Solvent: Diethyl ether, Hexane
Boiling Point:449.6°C at 760 mmHg
Flash Point:225.7±28.7 °C
Refractive Index:1.593
Water Solubility:soluble to 50 mM in DMSO
Storage Conditions:Store at RT
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Tamibarotene
1 KG May 27, 2025 Post an enquiry for this product
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