1-Chloro-4-iodobenzene

  Product Detail  

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• CAS Registry Number : 637-87-6 ​

• EINECS Number : 211-281-3 ​

• Molecular Formula : C₆H₄ClI ​

• Molecular Weight : 238.45 g/mol ​​

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• Appearance & Odor : White to off-white crystalline solid; odorless at room temperature; chemically stable under normal conditions. ​

• Melting Point : 53-54 °C (lit.) ​

• Boiling Point : 226-227 °C (lit.) ​

• Density : 1.931 g/cm³ (20 °C, crystalline state) ​​

• Purity Specification : Industrial grade ≥ 98.0% (GC/HPLC), total impurities ≤ 2.0% ( Reactivity : Stable under normal temperature and pressure; incompatible with strong oxidizing agents, strong bases, and active metals (e.g., sodium, potassium); may undergo coupling reactions (e.g., Suzuki coupling, Heck reaction) under catalytic conditions; avoid exposure to high temperature and open flames (may decompose to release toxic halogenated gases). ​

• Pharmaceutical Synthesis : Critical building block for aromatic substitution reactions, used in the synthesis of pharmaceutical intermediates such as heterocyclic compounds (e.g., quinazolines, benzimidazoles) and arylamine derivatives; applied in the R&D of anti-cancer, anti-inflammatory, and anti-viral drugs due to its ability to introduce functional groups into aromatic rings. ​

• Pesticide Synthesis : Used in the production of fungicides, insecticides, and herbicides; enhances the biological activity and environmental stability of pesticide molecules through halogen substitution. ​

• Material Science : Precursor for conjugated polymers (e.g., polyphenylene vinylene derivatives) and organic electronic materials (e.g., OLED intermediates); used in the synthesis of specialty dyes and pigments with improved color fastness. ​

• Organic Synthesis : Versatile reagent for cross-coupling reactions (Suzuki, Stille, Negishi reactions) in fine chemical production, enabling the formation of carbon-carbon bonds for complex molecule synthesis.