Anti hair loss Pure 99% finasterida Finasteride raw powder CAS 98319-26-7

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Finasteride More Info

Finasteride is a synthetic medication primarily used for treating benign prostatic hyperplasia (BPH) and male pattern hair loss (androgenetic alopecia). It functions as a selective inhibitor of the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT), a hormone implicated in both conditions.

Mechanism of Action

Finasteride specifically inhibits the Type II isoenzyme of 5-alpha-reductase, which is predominantly found in the prostate, seminal vesicles, and hair follicles. By blocking this enzyme, finasteride reduces DHT levels significantly—up to 91% in prostate tissue and about 70% in serum concentrations. This reduction leads to decreased stimulation of androgen receptors in the prostate, resulting in reduced prostate size and alleviation of urinary symptoms associated with BPH. The inhibition also helps prevent hair loss by reducing the effects of DHT on hair follicles

Uses

1. Benign Prostatic Hyperplasia (BPH):
Finasteride is prescribed at a dosage of 5 mg once daily to help reduce prostate size, alleviate urinary symptoms, and potentially delay the need for surgery.
2. Male Pattern Hair Loss:
For treating hair loss, the typical dosage is 1 mg once daily. It may take several months (usually 3 months or more) to notice improvements in hair growth and density.

Routes of Administration

Finasteride is administered orally in tablet form. It can be taken with or without food, and its absorption is not significantly affected by dietary intake. The bioavailability of finasteride is approximately 65%, with peak plasma concentrations occurring within 1-2 hours post-administration

Safety and Side Effects

While finasteride is generally well-tolerated, it can cause side effects, including:
Sexual dysfunction (decreased libido, erectile dysfunction)
Ejaculation disorders
Breast tenderness or enlargement
Potentially increased risk of high-grade prostate cancer with long-term use
These side effects may persist even after discontinuation of the medication. Regular monitoring by healthcare providers is recommended to manage any adverse effects effectively.

Pharmacokinetics

Absorption: The drug is well absorbed after oral administration, with a bioavailability of about 65%.
Distribution: Finasteride has a volume of distribution of approximately 76 L and is about 90% protein-bound in plasma.
Metabolism: It undergoes extensive hepatic metabolism primarily via the cytochrome P450 3A4 enzyme, producing metabolites that retain less than 20% of the pharmacological activity of finasteride.
Elimination: The elimination half-life ranges from 4.7 to 7.1 hours, with longer half-lives observed in older adults. Approximately 57% of the drug is excreted via feces and 39% through urine.

Precautions

Not for Women: Finasteride is not approved for use in women, particularly those who are pregnant or breastfeeding, due to potential risks to fetal development.
Monitoring: Regular monitoring of prostate-specific antigen (PSA) levels is recommended for men taking finasteride for BPH, as the drug can lower PSA levels and potentially mask prostate cancer.

Finasteride is a basic drug for the treatment of prostatic hyperplasia and prostatitis in China. It is a synthetic 4-azosterone compound, which is an anti-sex hormone drug that can selectively inhibit 5α-reductase, so that the process of converting testoster one into 5α-dihydrotestoster one (DHT) becomes blocked, the prostate cells in The actual androgen level decreases, the prostate-specific antigen in the serum decreases, the size of the enlarged prostate shrinks, and the urinary flow rate increases, thus reducing the patient's symptoms and achieving the purpose of treating prostate enlargement. The action of the drug is characterized by its ability to selectively block the stimulating effect of androgens on the prostate, yet it rarely affects the sexual function of men. Prostate enlargement, also known as prostate hypertrophy, causes compression of the bladder neck and posterior urethra, causing urinary obstruction and other symptoms and complications that are deeply painful for patients, mostly in the male population over 50 years of age.