High quality Organic Intermediate Ketoconazole Powder CAS 65277-42-1 Ketoconazole

Ketoconazole Cas 65277-42-1 is a synthetic antifungal drug used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet.

Hair loss
Ketoconazole shampoo in conjunction with an oral 5α-reductase inhibitor has been used off label to treat and rogenic alopecia.
The antifungal properties of ketoconazole reduce scalp microflora and consequently may reduce follicular inflammation that contributes to alopecia.Limited clinical studies suggest ketoconazole shampoo used either alone or in combination with other treatments may be useful in reducing hair loss. At least one study has been performed showing that ketoconazole may be useful in temporarily reducing erectile function in postoperative penile surgery patients.

Veterinary use
Ketoconazole Cas 65277-42-1 is also sometimes prescribed by veterinarians for use on pets, often as unflavored tablets that may need to be cut to smaller size for correct dosage.

Ketoconazole is usually prescribed for fungal infections of the skin and mucous membranes, such as athlete's foot, ringworm, candidiasis (yeast infection or thrush), jock itch, and tinea versicolor.
Topical ketoconazole Cas 65277-42-1 is also used as a treatment for dandruff (seborrheic dermatitis of the scalp) and for seborrheic dermatitis on other areas of the body, perhaps acting in these conditions by suppressing levels of the fungus Malassezia furfur on the skin.

Ketoconazole is an early synthetic imidazole derivative that was previously used systemically as a broad-spectrum antifungal agent. It works by inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, altering membrane permeability and leading to fungal cell death. However, due to the potential for severe hepatotoxicity and significant suppression of adrenal corticosteroid synthesis associated with its oral formulation, this route of administration has been withdrawn from the market or strictly restricted in most regions worldwide. Currently, its topical formulations are still used to treat dermatophytoses and pityriasis versicolor, while the oral form is reserved for specific serious fungal infections only when no alternatives exist and under close monitoring. It is crucial to emphasize that this is a high-risk prescription drug, and any use must involve a thorough physician assessment of the benefits versus the risks.

Ketoconazole is a synthetic imidazole antifungal that competitively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme essential for converting lanosterol to ergosterol in fungal membranes. Its broad-spectrum activity encompasses dermatophytes, Candida species, and systemic pathogens like Blastomyces dermatitidis, though resistance development has increased among C. glabrata isolates. The drug's high lipophilicity enables penetration into keratinized tissues, supporting topical use for seborrheic dermatitis and pityriasis versicolor, while systemic administration is restricted due to dose-dependent hepatotoxicity involving mitochondrial dysfunction and bile duct injury. Additional endocrine effects include suppression of gonadal and adrenal steroidogenesis through CYP17A1 inhibition, exploited in advanced prostate cancer and Cushing's syndrome management under rigorous supervision. Pharmacokinetic characteristics include pH-dependent absorption, extensive hepatic metabolism, and biliary excretion requiring acid-reducing agent avoidance. Despite safety limitations, ketoconazole remains a valuable diagnostic tool in endocrinology and a reference compound for antifungal susceptibility testing, with ongoing research exploring novel formulations for localized delivery without systemic exposure.

Q1  Can i get some samples
A1  Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2  How to start orders or make payments
A2  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.                Payment by T/T,or Paypal or Escrow(Alibaba).
Q3  How to confirm the Product Quality before placing orders
A3  You can get free samples for some products,you only need to pay the shipping cost or arrange a   courier to us and take the samples. You can send us your product specifications and requests,we  will manufacture the products according to your requests.
Q4  What's your MOQ
A4  Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5  How about delivery leadtime
A5  Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6  Is there a discount
A6  Different quantity has different discount.
Q7  How do you treat quality complaint
A7  First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8  How to contact us
A8 You can chat with us by Trademanager,MSN&Skype Online.
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