Best Price Factory Supplier Pimobendan CAS 74150-27-9

Pimobendan More Info

Pimobendan is a benzimidazole-pyridazinone compound classified as an inodilator, primarily used in veterinary medicine to manage heart failure in dogs. It exhibits both positive inotropic (increasing the force of heart contractions) and vasodilatory effects, making it effective for treating congestive heart failure due to conditions such as mitral valve insufficiency and dilated cardiomyopathy.

Mechanism of Action

Pimobendan's mechanism of action involves several key processes:
Calcium Sensitization: It enhances the sensitivity of cardiac troponin to calcium ions, which improves myocardial contractility without significantly increasing intracellular calcium concentration. This allows for more efficient heart contractions with lower energy consumption.
Phosphodiesterase III Inhibition: Pimobendan inhibits phosphodiesterase III (PDE3), leading to increased levels of cyclic adenosine monophosphate (cAMP). This results in vasodilation and reduced afterload, decreasing the workload on the failing heart.
Vasodilation: By relaxing vascular smooth muscle, pimobendan decreases systemic vascular resistance, which helps improve cardiac output and reduce pulmonary congestion.

Applications

Congestive Heart Failure: Used in dogs to treat heart failure resulting from valvular insufficiency or dilated cardiomyopathy.
Cardiac Support: It may be used as part of a broader treatment regimen for managing chronic heart conditions in veterinary practice.

Routes of Administration

Pimobendan is typically administered via:
Oral Tablets: Commonly prescribed for daily use in dogs.
Oral Solutions: Available for pets that may have difficulty swallowing tablets.

Safety and Side Effects

While generally well-tolerated, pimobendan can cause side effects, including:
Common Side Effects: Gastrointestinal issues such as vomiting, diarrhea, decreased appetite, and lethargy.
Serious Side Effects: Rarely, it may lead to more severe reactions like tachycardia (rapid heart rate), syncope (fainting), seizures, or allergic reactions (e.g., difficulty breathing).
Monitoring Required: Regular veterinary check-ups are essential to monitor for potential adverse effects, especially in patients with pre-existing conditions or those on concurrent medications.

Pharmacokinetics

Absorption: Rapidly absorbed after oral administration with a bioavailability of approximately 60–65%. Food intake can decrease its bioavailability.
Distribution: Highly protein-bound (90–95%) in circulation, which may affect its pharmacological effects and interactions with other drugs.
Metabolism: Primarily metabolized by the liver into an active metabolite called O-desmethylpimobendan (ODMP), which has additional pharmacological effects. The half-life of pimobendan is about 0.4 hours, while ODMP has a longer half-life of approximately 2 hours.
Elimination: Excreted mainly through bile and feces.

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Passion to innovate, Power to deliver !

Q1 Can i get some samples?

A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2 How to start orders or make payments?

A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T,or Paypal or Escrow(Alibaba).

Q3 How to confirm the Product Quality before placing orders?

A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier

to us and take the samples. You can send us your product specifications and requests,we will manufacture

the products according to your requests.

Q4 What’s your MOQ?

A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge

is 100% paid.

Q5 How about delivery leadtime?

A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6 Is there a discount?

A6 Different quantity has different discount.

Q7 How do you treat quality complaint?

A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem

caused by us, we will send you free goods for replacement or refund your loss.

Q8 How to contact us ?

A8 You can choose your interested products and send inquiry to us.