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Supply High Quality Citicoline Sodium/Citicoline CAS 33818-15-4

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CAS No.:

33818-15-4

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

HNB

Packaging:

25kg Cardboard Drum

Price valid (until):

2026-04-10

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HNB Biotech

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

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Product Description
Seller Information
Inquiry History

Description

Product Description

Citicoline Sodium More Info

Citicoline sodium, also known as cytidine-5'-diphosphocholine (CDP-choline), is a compound that serves as a precursor for the synthesis of phosphatidylcholine, a vital component of cell membranes. It has garnered attention for its potential neuroprotective effects and therapeutic applications in various neurological conditions.

Mechanism of Action

Citicoline is believed to exert its effects through several mechanisms:
1. Choline Donor: It acts as a donor of choline, which is essential for the synthesis of phospholipids, particularly phosphatidylcholine, crucial for maintaining cell membrane integrity and function.
2. Neuroprotective Properties: Citicoline may enhance neuronal survival and function by modulating phospholipid metabolism and neurotransmitter levels, thereby improving cognitive function in conditions such as stroke and bipolar disorder.
3. Angiogenesis: Recent studies suggest that citicoline induces angiogenesis, enhancing blood flow to the brain, which may further support neuronal health

Applications

Citicoline sodium has been investigated for several clinical applications:
Neurological Disorders: It is used in the treatment of stroke, bipolar disorder, hypomania, and cocaine dependence24.
Cognitive Enhancement: Some studies indicate potential benefits in improving cognition in patients with central nervous system disorders3.
Supportive Care: Citicoline is also considered for supportive care in various psychiatric conditions

Routes of Administration

Citicoline can be administered through various routes:
Oral Administration: Commonly available in tablet form.
Parenteral Administration: Can be given intravenously or intramuscularly, which allows for faster absorption and action.

Safety and Side Effects

Citicoline is generally well-tolerated, with few reported side effects. Commonly noted side effects include:
Gastrointestinal disturbances (e.g., nausea)
Headaches
Insomnia
Serious adverse effects are rare, making it a relatively safe option for many patients

Pharmacokinetics

The pharmacokinetics of citicoline sodium reveal important characteristics:
Absorption: After administration, citicoline is quickly metabolized into choline and cytidine. Studies show that plasma concentrations peak at approximately 15 minutes post-intravenous administration, with a second peak around 5 hours later.
Distribution: It has a moderate ability to cross the blood-brain barrier, which is crucial for its neuroprotective effects.
Metabolism: Citicoline undergoes rapid hydrolysis to yield its active metabolites, including cytidine monophosphate (CMP) and phosphocholine (PCho).

Items	Specifications
Name	Citicoline sodium
CAS	33818-15-4
Molecular formula	C14H26N4O11P2.Na
Density	511.31

About Us

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trust wortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Passion to innovate, Power to deliver !

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FAQ

Q1 Can i get some samples?

A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2 How to start orders or make payments?

A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T,or Paypal or Escrow(Alibaba).

Q3 How to confirm the Product Quality before placing orders?

A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier

to us and take the samples. You can send us your product specifications and requests,we will manufacture

the products according to your requests.

Q4 What’s your MOQ?

A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge

is 100% paid.

Q5 How about delivery leadtime?

A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6 Is there a discount?

A6 Different quantity has different discount.

Q7 How do you treat quality complaint?

A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem

caused by us, we will send you free goods for replacement or refund your loss.

Q8 How to contact us ?

A8 You can choose your interested products and send inquiry to us.

Certificates

Basic Info

Product Name:

Citicoline sodium

Other Name:

Cytidine 5′-(trihydrogen diphosphate),P′-[2-(trimethylammonio)ethyl] ester,inner salt,sodium salt (1:1);Cytidine 5′-(trihydrogen diphosphate),P′-[2-(trimethylammonio)ethyl] ester,hydroxide,inner salt,monosodium salt;Choline,hydroxide,monoester with cytidine 5′-(trihydrogen pyrophosphate),inner salt,monosodium salt;Cytidine 5′-(trihydrogen diphosphate),P′-[2-(trimethylammonio)ethyl] ester,inner salt,monosodium salt;IP 302 sodium;Citicoline sodium;Cebroton;Brassel;Acticolin;Neurotron;Gerolin;Sinkron;Cidifos;Logan;Flussorex;CerAxon;Strolin;126832-19-7

CAS No.:

33818-15-4

Molecular Formula:

C14H26N4O11P2.Na

InChIKeys:

InChIKey=GBRJGMTWFZWCCU-OCMLZEEQSA-N

Molecular Weight:

510.31

Exact Mass:

510.08927590 g/mol

EC Number:

251-689-1

UNII:

7XQ5AKD9YD

DSSTox ID:

DTXSID4048981

ATC Code:

N - Nervous system

HScode:

2934999090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

238.17000

XLogP3:

-0.14090

Appearance:

white solid

Melting Point:

259-268°C (dec.)

Water Solubility:

soluble in water (100 mg/ml).

Storage Conditions:

2-8°C

Specific rotation:

D20 +12.5° (c = 1.0 in H2O)

Collision Cross Section:

210.4 Å² [M-2H+Na]-

See More Citicoline sodium Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Citicoline sodium Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

Location:
6 floor Baoyilongji Building B Weiyang Area, Fengcheng 8 Road, Xi'an city, Shaanxi, 710000, China

Payment Terms:
L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2017

Certifications:
ISO,ISO

Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian

International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is the

leading researcher and one of the biggest manufacturer in high technology API area.

There are 8 experts in our research team. We insist in innovation and produce high quality

products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales departments over 20 people and sell our products all over the world.

We also have strong professional research and development team, talented personnel and

completely equipped laboratory for the quality controlling. Various Detection Device is

equipped in HNB company, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto

titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

HNB mainly engaged in export of products including, without limitation, pharmaceutical raw

materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant

extract, feed and food additives.

Our company's business is based on Honest, Trustworthy, Constantly to Go Beyond and

Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends

from both home and abroad.

Passion to innovate, Power to deliver !

Inquiry History

15 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	Citicoline sodium	750.00 G	Aug 14, 2024
Egypt	Citicoline Sodium	500.00 KG	Jan 27, 2026
Swaziland	Citicoline Sodium	1 KG	Jun 4, 2024
Switzerland	Citicoline sodium	5 MT	Feb 28, 2024
India	Citicoline	500.00 KG	Jun 28, 2024
India	Citicoline sodium	500 KG	Jul 4, 2025
Russia	PRL-8-53	10.00 G	Aug 14, 2024
Russia	Sofosbuvir	68.00 G	Aug 14, 2024
Russia	Enclomiphene	100.00 G	Aug 14, 2024
Russia	7,8-Dihydroxyflavone	75.00 G	Aug 14, 2024
Russia	NNMTi	15.00 G	Aug 14, 2024
Russia	Velpatasvir	17.00 G	Aug 14, 2024
Russia	Unifiram	30.00 G	Aug 14, 2024
Russia	Coluracetam	100.00 G	Aug 14, 2024
Russia	DIHEXA	50.00 G	Aug 14, 2024

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