Tirzepatide 30mg Lyophilized Powder 99% Purity GLP-1 Peptide Weight Loss Raw Material CAS 2023788-19-2

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Tirz is a novel, once weekly, dual GIP/GLP-1 receptor agonist and is under development for the treatment of type 2 diabetes (T2D) and obesity. 

Tirz is a dual glucose-dependent insulinotropic polypeptide-GLP-1 receptor agonist. Its structure is primarily based on the glucose-dependent insulinotropic polypeptide amino acid sequence and includes a C20 fatty diacid moiety. Its half-life of approximately 5 days allows once-weekly subcutaneous administration. A phase 2b trial involving patients with type 2 diabetes showed that those who received Tirz had dose-dependent reductions in the glycated hemoglobin level and weight at 26 weeks.
Once-weekly injectable Sema, a selective GLP-1 receptor agonist, is approved for the treatment of type 2 diabetes at doses up to 1 mg. In trials involving patients who received Sema, the mean reductions in the glycated hemoglobin level have been reported to be as high as 1.8 percentage points and the mean reductions in body weight have been reported to be as high as 6.5 kg.

 The addition of GIP which anatagonizes the central effects of GLP-1 to cause nausea is designed to improve tolerability and also allow for more aggressive dosing with increased systemic exposure. A recent post-hoc analysis showed significantly decreased NASH-related biomarkers and increased adiponectin in patients with T2DM

  The weight-reducing actions of the GIPR-GLP1R co-agonist tirzepatide.Considerable interest is focused on the mechanisms of action of tirzepatide, a highly effective GIPR-GLP1R co-agonist that produces superior reductions in HbA1c and body weight, relative to that achieved with 1 mg once weekly of semaglutide in people with T2D. The GIPR is expressed in multiple regions of the mouse and human brain, in subsets of neurons and glial cells, with some hypothalamic and hindbrain cells exhibiting co-expression of the GIPR and GLP1R. Chemogenetic activation of GIPR + cells in the mouse hypothalamus acutely reduced food intake; however, co-administration of exendin-4 did not produce an additive reduction of food intake when compared to either intervention alone.

Our company is mainly engaged in peptides, synthetic peptide amino acids, beauty and weight-loss products, as well as raw materials for beauty and freckle-removing cosmetics, all of which are of reliable quality. We are committed to strict quality control and thoughtful customer service, and our experienced staff are always ready to discuss your requirements to ensure your satisfaction.

Our business philosophy is summarized as "Quality First, Service Foremost". We firmly believe that prioritizing quality in all aspects of our operations and providing excellent service lay a solid foundation for long-term success. Our mission is to lead the advancement of biotechnology by consistently adhering to the highest standards of quality and service, and we strive to contribute to improving global health through innovation and excellence.

We focus on providing high-quality products, competitive prices, flexible order quantities and timely delivery. Our products are mainly exported to European countries, the United Kingdom, the United States, Canada and Australia. With extensive export experience, we have never encountered any customs clearance issues so far.

By focusing on sourcing high-quality raw materials and ensuring strict internal process control, our products have been widely recognized and trusted by users around the world. We will continue to uphold our business philosophy, optimize our product and service system, and strive to become a reliable partner in the global biotechnology field.

Q1: About the after-sale service
A: After purchasing the products from our Lab, we have A professional technical team and after-sales team to serve you and solve all your problems in the future
Q2:  I want to know more details about the product, how can I contact you?
A: You can send us an email inquiry at any time. For more accurate quotes, I need the following information: product name, order quantity, receipt country, quality requirements, etc.
Q3: Can I get some samples?
A:Yes, we can provide samples, but the customer will pay the shipping cost.
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A: We will respond to your message in a timely manner. We guarantee to respond to you within 24 hour
Q5: What is your MOQ?
A: The minimum quantity we can order is 1 box.
Q6: Can you give me a discount price?
A:Surely,It depend on your quantity. 
Q7:  How to preserve peptides after receiving them?
A:Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2 ° C - 8 ° C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20 ° C or -80 ° C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.