Glycyrrhizin is a natural active compound extracted from the traditional Chinese medicine licorice. It is a white crystalline powder and belongs to the flavonoid category.
Its chemical name is glycyrrhizin-4′-β-glucoside, with the molecular formula of C21H22O9 and the CAS number of 551-15-5.
Glycyrrhizin has clear pharmacological activities and is applied in medical research, food industry and cosmetics.
I. Basic Properties and Pharmacological Effects
Glycyrrhizin is mainly extracted from the roots and rhizomes of the leguminous plant Glycyrrhiza uralensis. Its purity is usually above 98%.
Its physical properties are that it is insoluble in water but soluble in methanol. The melting point is 212-213℃. It should be stored under refrigeration at 4℃, sealed, and protected from light.
In terms of pharmacological effects, glycyrrhizin exhibits a wide range of biological activities:
Anti-inflammatory and Immune Regulation: Glycyrrhizin and its related derivatives (such as glycyrrhizic acid glycosides) can inhibit the production of inflammatory factors such as prostaglandins, thereby reducing tissue inflammatory responses.
At the same time, it also has a bidirectional immune regulation function, which can both inhibit excessive immune responses and enhance the body's anti-viral ability.
Protecting the Mucosa and Anti-Ulceration: Glycyrrhizin helps stimulate the secretion of gastric mucus, forming a protective layer on the surface of the gastrointestinal mucosa, reducing the irritation caused by gastric acid, and has an auxiliary therapeutic effect on gastric ulcers and duodenal ulcers.
Cough and Phlegm Relieving: This ingredient can stimulate the secretion of the bronchial mucosa, dilute the phlegm, and has a relieving effect on respiratory system diseases such as acute and chronic bronchitis, and cold-induced cough.
Detoxification and Modulation of Drug Properties: In the combination of traditional Chinese medicines, components related to glycyrrhizin can reduce or moderate the toxicity or harshness of certain drugs, playing a role of coordination and neutralization.
Other potential activities: The research also indicates that glycyrrhizin has antioxidant and anti-HIV effects.
II. Main Application Areas
Due to its pharmacological properties, glycyrrhizin powder has been applied in several fields:
Pharmaceutical Research and Development: High-purity licorice glycoside powder (available in specifications ranging from 20mg to 500g) is mainly used for content determination, pharmacological experiments, and activity screening for scientific research purposes.
It is one of the key raw materials for developing auxiliary drugs to treat chronic liver diseases, allergic diseases, and autoimmune diseases.
Food Industry: Glycyrrhizin can be used as a natural sweetener or flavor enhancer and can be added to traditional pastries, candies, and other foods.
When using it, the dosage must be strictly controlled to avoid excessive intake.
Daily Health Care and Mixture with Traditional Chinese Medicine: Under the guidance of traditional Chinese medicine theory, glycyrrhizin-containing licorice powder is often used to relieve symptoms such as sore throat and excessive coughing and phlegm, and is commonly used in combination with medicinal materials such as honeysuckle, apricot kernels, and aniseed.
It is also used to alleviate the bitterness of traditional Chinese medicine prescriptions and enhance the taste.
III. Usage Notes
Although glycyrrhizin has a wide range of applications, its use must follow scientific principles and be mindful of potential risks:
Dosage and Treatment Duration: Regardless of whether it is taken internally or applied externally, excessive use is not recommended. For daily health care, it is suggested to take it continuously for no more than 2 weeks, and the daily dosage should generally not exceed 10 grams.
Side effects and contraindications: Long-term or excessive use may lead to water and sodium retention, elevated blood pressure, hypokalemia and other symptoms of pseudo-aldosterone hypersecretion.
People with hypertension, pregnant women, those with impaired kidney function, and those taking diuretics or cardiac glycosides should use it with caution or under the guidance of a doctor.
Drug compatibility contraindications: Avoid using together with seaweed, houttuynia cordata, and aconite, which are traditionally considered "opposite" in terms of compatibility.
Storage requirements: The product should be stored in an airtight container and kept in a cool, dry place to prevent moisture absorption, clumping, or discoloration, which could affect its efficacy.
In conclusion, glycyrrhizin powder is a natural product with a clearly defined chemical structure and multiple biological activities. Its application should be based on a thorough understanding of its efficacy and risks, especially in medical applications, where professional guidance should be followed.
| Items | Specifications |
| Name | LIQUIRITIN(SH) |
| CAS | 551-15-5 |
| Molecular formula | C21H22O9 |
| Density | 418.4 |
Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.
There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.
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