Palmitoyle Tripeptide-1(Pal-GHK)

A peptide is two or more amino acids joined together and is the building block of protein. Peptides fall into three main categories: signal peptides, carrier peptides, and those that inhibit nerve signals. Signal peptides, like palmitoyl tripeptide-1, act as messengers to cells, which trigger collagen synthesis, which then increases skin firmness.Palmitoyl tripeptide-1 is a small three amino acid signal peptide with the amino sequence of glycine-histidine-lysine (GHK). GHK is attached to palmitic acid (a fatty acid) to increase its skin penetration and oil solubility.
Pal-GHK is a form of the extracellular matrix-derived peptide GHK containing palmitic acid , which allows it to penetrate the stratum corneum to the epidermal and dermal skin layers. Pal-GHK (0.5 μM) increases collagen synthesis in human skin fibroblastsin vitro. It reduces collagen degradationex vivoin patient-derived human skin samples irradiated with UVA light when used at a concentration of 6 ppm. It has been used with the zwitterionic surfactant C12dodecyldimethylamine oxide (C12DMAO) to study self-assembly of the mixture into aggregates, ribbons, and nanobelts. Pal-GHK has also been used as an internal standard for the quantification of pal-KTTKS in anti-wrinkle creams by LC-MS/MS.