Natural Carnosine Dihydrochloride Bright Firm Anti Aging Skin Barrier Care Essence

1. Description

Carcinine dihydrochloride (also known as β-alanine histamine, decarboxy-myostatin hydrochloride, or Alistin) is a naturally occurring peptide derivative composed of a β-alanine residue and histamine, featuring an imidazole ring. In mammals, carcinine is distributed in tissues such as the brain, muscles, intestines, and liver. As a selective histamine H3 receptor antagonist, its selectivity for H3 receptors is 100 to 1,000 times higher than that for H2 and H1 receptors. Additionally, casinine possesses antioxidant properties, capable of scavenging reactive oxygen species (ROS) generated during lipid oxidation and providing protection against oxidative damage to photoreceptor cells. It demonstrates neuroprotective effects on the mouse retina in oxidative stress models. It also acts as a chemical chaperone, reducing non-enzymatic glycation of proteins and maintaining their native folded state. In the field of skincare, cassinine helps counteract the negative effects of environmental stressors on the skin through its anti-glycation and antioxidant properties. It protects collagen, slows cellular metabolism, and exerts anti-aging effects. Widely used in neuroscience, dermatology, anti-aging research, and cell protection, it is a multi-target active molecule that combines H3 antagonism, antioxidant activity, and anti-glycation functions.

2. Application

(1) Research on neurodegenerative diseases: Used to study its effects on the degeneration of dopaminergic neurons and to explore its potential protective role in diseases such as Parkinson’s disease.

(2) Research on ophthalmic diseases: Used in models of oxidative stress-induced retinal damage to study its protective effects on photoreceptor cells.

(3) Inflammation and Immunology Research: As a histamine H3 receptor antagonist, it is used to investigate mechanisms of inflammatory response regulation and immune modulation.

(4) Cardiovascular Disease Research: To explore its positive inotropic effects and potential for regulating cardiac function.

(5) Metabolic Disease Research: To investigate its role in regulating blood glucose and lipid levels, and to explore potential applications in metabolic diseases such as diabetes.

3. Main Efficacy

(1) Selective histamine H3 receptor antagonism: As a highly selective histamine H3 receptor antagonist, its affinity (Ki value of 0.2939 μM) is significantly higher than its affinity for H2 and H1 receptors. By blocking H3 receptors, it modulates histaminergic neurotransmission and influences various physiological functions, including wakefulness, cognition, and appetite.

(2) Antioxidant Effects and Scavenging of Lipid Peroxidation Products: It scavenges 4-hydroxy-2-nonenal (4-HNE), a toxic byproduct of lipid oxidation, thereby reducing oxidative stress-induced cellular damage. It exhibits a protective effect against oxidative damage in photoreceptor cells. Additionally, it possesses lipid peroxidase activity.

(3) Neuroprotective Effects: In retinal oxidative stress models, it protects photoreceptor cells from damage through 4-HNE scavenging and antioxidant activity. Studies also suggest it may have a potential protective effect against dopaminergic neuron degeneration.

(4) Chemo-chaperone Activity: As a chemo-chaperone, it reduces non-enzymatic glycation of proteins and maintains their normal folding state.

(5) Positive inotropic effect: It enhances myocardial contractility, which may have a positive impact on cardiac function.

(6) Metabolic regulatory effects: It can lower blood glucose and lipid levels, suggesting potential clinical applications in metabolic disorders such as diabetes and hyperlipidemia.