High Qauality Nad+ safe delivery

Contacts with us

Name: Wein

Whatsapp: +85264221056

1. Core Molecular & Physical Traits

2. Core Biological Functions

• Energy Production: Acts as a redox carrier in glycolysis, TCA cycle, and oxidative phosphorylation (OXPHOS), enabling ATP synthesis via NAD+ ↔ NADH electron transfer.
• DNA Repair: Serves as a cofactor for PARPs (poly-ADP-ribose polymerases) to fix single-strand and double-strand DNA breaks.
• Longevity & Epigenetics: Activates sirtuins (SIRT1–7) to regulate gene expression, mitochondrial function, and stress resistance.
• Mitochondrial Health: Supports OXPHOS efficiency and protects against oxidative damage via sirtuin activation.
• Cellular Signaling: Consumed by CD38/CD157 (NADases) and PARPs, linking to immune response and cell death pathways.

3. Metabolism & Homeostasis

• 1. De novo: Tryptophan → kynurenine pathway → NAD+ (liver-dominant).
  2. Preiss-Handler: Nicotinic acid (NA) → NAMN → NAAD → NAD+.
  3. Salvage: Nicotinamide (NAM)/NMN/NR → NMN → NAD+ (main pathway in most tissues).
• Consumption: Sirtuins, PARPs, CD38/CD157, and SARM1 drive NAD+ turnover; balance with synthesis maintains levels.
• Decline Factors: Aging (30% drop per 20 years), high energy demand, inflammation, alcohol, and metabolic diseases.

4. Health Benefits & Research Insights

5. Supplementation & Precautions

• Common Precursors:
  • NMN (Nicotinamide Mononucleotide): Direct precursor, rapidly converts to NAD+ in vivo.
  • NR (Nicotinamide Riboside): Converts via NR kinase to NMN → NAD+.
  • Nicotinamide (NAM)/Nicotinic Acid (NA): Salvage pathway precursors; NA may cause flushing.
• Safety:
  • Precursors (NMN/NR) are generally well-tolerated at typical doses (250–1000 mg/day).
  • High NAM may inhibit sirtuins/PARPs; NA can cause transient flushing/itching.
  • Avoid in pregnancy/lactation (insufficient data); consult a doctor with chronic conditions.
•