Myristoyl Hexapeptide-16 for Skin Firming Anti-wrinkle and Collagen Boosting

1. Description

Myristoyl Hexapeptide-16 is a synthetic peptide composed of six amino acid residues, modified by a myristoyl (tetradecanoic acid) fatty acid chain attached to its N-terminus; it belongs to the class of fatty acid peptides. It appears as a white to off-white powder. This compound is soluble in water and dimethyl sulfoxide (DMSO) and exhibits good water solubility. Storage conditions: The powder can be stored for 3 years at -20°C and for 2 years at 4°C; when dissolved in a solvent, it can be stored for 6 months at -80°C. This ingredient has been included in the International Cosmetic Ingredient Nomenclature (INCI), with trade names including Syn-Glycans and Pro-Coll-One+.

2. Application

(1) Skincare and Anti-Aging Products: As a functional ingredient in anti-wrinkle and firming skincare products, it is added to creams, serums, eye creams, face masks, and other products to improve skin elasticity and reduce wrinkles.

(2) Research on Collagen Synthesis: Used to study the mechanisms underlying the enhancement of Type I, III, and IV collagen and fibronectin synthesis; it can serve as a collagen promoter in skincare and regenerative medicine research.

(3) Research on Damaged Skin Repair: Used to investigate the mechanisms underlying enhanced skin repair capacity and improved skin barrier function, with applications in scenarios such as post-sun exposure skin repair and post-aesthetic procedure recovery.

(4) Basic Research Applications: Serves as a model molecule for fatty acid-modified peptides, used to study the effects of fatty acid modification on peptide segment permeability and biological activity.

3. Main Efficacy

(1) Promotes collagen synthesis: In vitro studies have shown that Myristoyl Hexapeptide-16 significantly enhances the synthesis of Type I, III, and IV collagen, as well as fibronectin. Type I collagen is the primary structural component of the skin; Type III collagen is associated with skin elasticity; Type IV collagen is a key component of the basement membrane; and fibronectin plays a role in cell adhesion and wound healing processes.

(2) Anti-wrinkle and skin firming: By promoting the production of various types of collagen and extracellular matrix proteins, it strengthens the skin’s supportive structure, improves skin elasticity, reduces the depth of fine lines and wrinkles, and delivers anti-aging benefits.

(3) Enhancing Skin Repair Capacity: By promoting the synthesis of fibronectin and Type IV collagen, it enhances the integrity of the basement membrane and accelerates the skin barrier repair process. It is valuable for skin repair following cosmetic procedures (such as laser treatments or chemical peels) or after sun damage.

(4) Extracellular Matrix Remodeling: As an extracellular matrix regulatory peptide, it participates in the maintenance and remodeling of collagen fibers and the basement membrane structure, helping to maintain the integrity and stability of the skin structure.

(5) Superior Skin Permeability: N-terminal myristoylation enhances the lipophilicity of the peptide segment, making it more easily able to penetrate the skin’s stratum corneum compared to unmodified peptides, thereby improving bioavailability and efficacy.