China Professional Supplier Calcium N5-methyltetrahydrofolate CAS

This substance is the main active circulating form of folic acid in the human body, and it is also the main form of free folic acid present in plasma and cells.
Compared to ordinary synthetic folic acid, its core advantage lies in the fact that it can be directly absorbed and utilized by the human body without undergoing the complex metabolic transformation in the liver, and it has a higher bioavailability.
Due to its highly oxygen-sensitive molecular structure, it is often made into calcium salt crystal form to enhance stability and extend the storage time.

In terms of physiological functions and applications, calcium 5-methyltetrahydrofolate mainly participates in the following key processes:
One-carbon unit metabolism and homocysteine regulation: As a key methyl donor, it participates in the cycle of converting homocysteine to methionine through re-methylation. This process is crucial for maintaining normal levels of homocysteine in the blood, and high levels of homocysteine are risk factors for cardiovascular diseases and neurological disorders.
DNA Synthesis and Cell Division: Directly involved in the synthesis of purines and thymine, it is the foundation of cell division and growth, and plays an important role in preventing megaloblastic anemia.
Neurological and Mental Health Support: By participating in the synthesis of S-adenosylmethionine, it affects the metabolism of neurotransmitters (such as serotonin, dopamine), and has a positive effect on maintaining normal neurological function and emotional regulation.
Epigenetic regulation: Provides methyl groups for the methylation of DNA, RNA and proteins, and participates in the regulation of gene expression.
Based on these functions, its application fields are extensive:
Nutrition supplementation and special population health management: Especially suitable for individuals with MTHFR gene mutations and folate metabolism disorders, as well as those whose folate absorption is affected due to gastrointestinal diseases or liver dysfunction.
For pregnant women and lactating women, supplementing with active folate helps prevent neural tube defects in the fetus.
Clinical supportive therapy: It has been used in clinical practice in regions such as Europe, involving the control of hyperhomocysteinemia, the auxiliary management of cardiovascular diseases, prenatal care, as well as the supportive treatment of neurological disorders such as depression and dementia.
Pharmaceuticals and Food Industry: Used as active ingredients in drugs or as food nutrient fortifiers. The U.S. Food and Drug Administration has recognized it as a generally recognized as safe substance and it can be used as food and drug additives.
Combined medication: Studies have shown that when used in combination with drugs such as progestogens, it may play a role in treating endometriosis and reducing pregnancy-related risks.
In the production process, folic acid is usually used as the starting material. Through multiple steps of reactions such as reduction, stereoselective transformation, and methylation, L-5-methyltetrahydrofolate is generated. Finally, it is salted with calcium ions and crystallized for purification to obtain a product with high purity and stability.
In the market, this product must comply with relevant pharmacopoeia standards (such as USP), and its purity is usually not lower than 99%.

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Passion to innovate, Power to deliver !

Q1 Can i get some samples?

A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2 How to start orders or make payments?

A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T,or Paypal or Escrow(Alibaba).

Q3 How to confirm the Product Quality before placing orders?

A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier

to us and take the samples. You can send us your product specifications and requests,we will manufacture

the products according to your requests.

Q4 What’s your MOQ?

A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge

is 100% paid.

Q5 How about delivery leadtime?

A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6 Is there a discount?

A6 Different quantity has different discount.

Q7 How do you treat quality complaint?

A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem

caused by us, we will send you free goods for replacement or refund your loss.

Q8 How to contact us ?

A8 You can choose your interested products and send inquiry to us.