78755-81-4Flumazenil
5 Inquiries
78755-81-4
pharmaceutical grade
99%
1
Ipure
25kg/Cardboard Drum
2026-05-20
pharmaceutical intermediates,chemical
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceFlumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
Solid
Flumazenil is an organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose. It has a role as a GABA antagonist and an antidote to benzodiazepine poisoning. It is an ethyl ester, an organofluorine compound and an imidazobenzodiazepine.|Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.|Flumazenil is a Benzodiazepine Antagonist.|Flumazenil is an imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner.|A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.Basic Info-
Product Name:
Flumazenil
Other Name:4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid,8-fluoro-5,6-dihydro-5-methyl-6-oxo-,ethyl ester;Ro 15-1788;Flumazenil;Anexate;Flumazepil;Ro 151788;Romazicon;Flumenazil;Ro 41-8157;Ro 1722;Mazicon;Lanexat;Ro 15-1788/000
CAS No.:78755-81-4
Molecular Formula:C15H14FN3O3
InChIKeys:InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N
Molecular Weight:303.29
Exact Mass:303.29
EC Number:1308068-626-2
UNII:40P7XK9392
NSC Number:759193
DSSTox ID:DTXSID2023064
NCI Thesaurus Code:C47534
ATC Code:V - Various
HScode:2933990090
Categories:
Characteristics-
PSA:
64.4
XLogP3:1
Appearance:white solid
Density:1.4±0.1 g/cm3
Melting Point:201-203 °C
Flash Point:273.1±30.1 °C
Refractive Index:1.634
Water Solubility:H2O: 128 mg/L;soluble in DMSO to 25mM
Storage Conditions:2-8°C
Toxicity:LD50 in mice, rats (mg/kg): 4000, 1360 i.p.; 4300, 6000 orally (Hunkeler)
Collision Cross Section:165.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|165.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Inhalation
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H312+H332 Harmful in contact with skin or if inhaled
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317 Get medical help.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
pharmaceutical intermediates,chemical
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Location:
Company Office Address: Room 1508, 15/F, Yate Centre Office Tower 2, 625 Nathan Road, Mong Kok, Hong Kong
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Payment Terms:
TT against copy of documents,D/P,L/C,O/A,100% TT in advance
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Average lead Time:
10
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2025
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted
Bahrain
Pharmaceutical Raw Material Central Nervous System Antagonist Flumazenil API Chemical Flumazenil CAS 78755-81-4 99% White Powder HHD
0.1 KG Nov 1, 2023
Australia
Flumazenil
1 G Dec 2, 2024
Pakistan
Flumazenil
10 G Aug 13, 2024
United States
Flumazenil
10 G Aug 2, 2024
Australia
Flumazenil
1 G Apr 19, 2026 Post an enquiry for this product
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