high-purity Nicotinamide riboside chloride-NAD+Boosting precursor for cellular energy&anti-aging formulations

Nicotinamide riboside is the precursor of nicotinamide adenine dinucleotide (NAD), and represents a source of vitamin B3. Recent studies have shown that consuming a greater amount of nicotinamide riboside than that naturally present in food can provide new health benefits. Nicotinamide mononucleotide plays an important role in the energy production of human cells and participates in the synthesis of NAD (nicotinamide adenine dinucleotide, an important coenzyme for cellular energy conversion) within cells. Nicotinamide riboside chloride is a crystalline form of nicotinamide riboside (NR) chloride, known as NIAGEN, and is generally considered safe (GRAS), and can be used in food and dietary supplements. Nicotinamide riboside is the source of vitamin B3 (niacin) and can enhance oxidative metabolism and prevent metabolic abnormalities caused by a high-fat diet. Nicotinamide riboside is a newly discovered NAD (NAD+) precursor vitamin.

Nicotinamide riboside has been shown to increase tissue NAD levels, induce insulin sensitivity, and enhance the function of deacetylases (sirtuins). Its ability to increase NAD production indicates that nicotinamide riboside can also improve mitochondrial health, stimulate mitochondrial function, and induce the generation of new mitochondria. Other studies using nicotinamide riboside in Alzheimer's disease models have shown that this molecule has bioavailability in the brain and may provide neuroprotective effects by stimulating NAD synthesis in the brain. Additionally, a 2012 study observed that mice fed a high-fat diet supplemented with nicotinamide riboside (Chemicalbook) had 60% less weight gain compared to mice fed the same high-fat diet without nicotinamide riboside. Nicotinamide riboside chloride (3-aminoformyl-1-[(2R,3R,4S5R)-3,4-dihydroxy-5-(hydroxymethyl)oxirane-2-yl]-pyridine-1-amine chloride; also known as 1-(β-D-ribofuranose) nicotinamide chloride) is the known salt form of nicotinamide riboside. Although the useful properties of nicotinamide riboside and its chloride salts (such as in pharmaceuticals or nutritional supplements) exist, improvements are often necessary.

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• Anti-aging potential
  Animal experiments have shown that NR can delay the decline in mitochondrial function, muscle atrophy, and neurodegeneration associated with aging. For instance, a 2016 study in the journal Science revealed that NR extended the lifespan of mice and improved metabolic indicators. However, human clinical trials are relatively small in scale and further verification is needed.
  Improving metabolic health
  Some studies suggest that NR may regulate glucose and lipid metabolism by activating sirtuins (longevity proteins). A 2020 experiment in "Nature Communications" found that NR could improve insulin sensitivity and liver fat content in obese individuals, but the effect varied from person to person.
  Protecting the nervous system
  NAD+ is crucial for the survival and function of neurons. Preclinical studies have shown that NR may alleviate cognitive impairment in mice with Alzheimer's disease models and alleviate symptoms of neuroinflammatory diseases such as multiple sclerosis, but human data is limited.
  Cardiovascular support
  NAD+ is involved in regulating vascular endothelial function. Preliminary studies have shown that NR can reduce the vascular stiffness of patients with hypertension, but no definite conclusion has been reached yet.