Product Name: PE 22-28
Synonym: Spadin analog, TREK-1 inhibitor peptide
CAS No.: 1801959-12-5
Amino Acid Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg（GVSWGLR）
Molecular Formula: C₃₅H₅₅N₁₁O₉
Molecular Weight: 773.88 g/mol
Appearance: White to off-white sterile lyophilized powder
Purity: ≥98%~99% (Tested by HPLC)
Identity: Confirmed by Mass Spectrometry (MS)
Endotoxin: ≤0.5 EU/mg
Water Content (Karl Fischer): ≤8.0%
Standard Specification: 5mg/10mg per vial
Target: Selective TREK-1 (KCNK2) potassium channel antagonist, IC₅₀=0.12 nM
Application: For laboratory research use only, not for human or animal consumption
PE 22-28 is a synthetic linear heptapeptide derived from the active fragment of Spadin , the shortest sequence that fully retains potent TREK-1 channel inhibitory activity, and its activity is about 300 times higher than the parent peptide Spadin.
It can specifically block TREK-1 two-pore domain potassium channel in neurons, induce neuronal depolarization, promote the release of serotonin, up-regulate BDNF expression in hippocampus, exert rapid-onset antidepressant, neuroprotective effects. It is widely used in preclinical research on major depressive disorder, stroke post-depression, neurodegenerative diseases, central nervous system neuroprotection and neuronal ion channel mechanism study.
Our PE 22-28 adopts sterile solid-phase peptide synthesis process, each batch is verified by HPLC & MS dual testing, official third-party COA report can be provided.
Lyophilized powder (unreconstituted): Store sealed at -20°C, protected from light and moisture, shelf life up to 24 months.
Reconstituted solution: Store at 2~8°C, use within 30 days; avoid repeated freeze-thaw cycles.
Equilibrate the vial to room temperature before opening to prevent condensed water from affecting product purity.
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