Dl-Homocysteine Thiolactone Hydrochloride CAS No 6038-19-3 High quality DL-Homocysteinethiolactone hydrochloride

DL-Homocysteinethiolactone hydrochloride is a chemically modified derivative of homocysteine, commonly used in biochemical and pharmaceutical research. It appears as a white to off-white crystalline powder and is water-soluble.

DL-Homocysteinethiolactone hydrochloride is a cyclic thioester derivative of the amino acid homocysteine. It is formed by the intramolecular condensation of homocysteine, resulting in a stable five-membered lactone ring structure. This compound is widely used as a precursor for generating homocysteine in biochemical and physiological research, as free homocysteine is highly reactive and unstable under laboratory conditions. The thiolactone form allows for controlled release and study of homocysteine's biological effects. It plays a significant role in understanding the mechanisms of hyperhomocysteinemia, a condition associated with cardiovascular disease, neurodegenerative disorders, and pregnancy complications. Additionally, this compound is employed in studies of protein homocysteinylation, a post-translational modification that can alter protein function and contribute to cellular stress. Its well-characterized chemical properties make it a valuable reagent for both basic science and translational research applications.

Beyond its role in homocysteine research, DL-Homocysteinethiolactone hydrochloride is also utilized in the study of sulfur-containing amino acid metabolism and redox biology. The thiolactone ring structure is highly reactive toward primary amines, allowing it to acylate lysine residues on proteins under physiological conditions. This unique reactivity makes the compound a valuable tool for investigating the biochemical consequences of non-enzymatic protein modifications, which are implicated in aging and age-related diseases. Furthermore, researchers often employ this compound in cell culture models to experimentally induce mild hyperhomocysteinemia, enabling the study of cellular adaptive responses and potential therapeutic interventions. Its stability in powder form and ease of dissolution in aqueous buffers contribute to its widespread use in both academic and pharmaceutical research settings. For industrial applications, DL-Homocysteinethiolactone hydrochloride serves as a key intermediate in the synthesis of homocysteine-containing peptides and other sulfur-bearing bioactive molecules.

DL-Homocysteinethiolactone hydrochloride is a white to off-white crystalline powder. It is freely soluble in water, The compound has a characteristic odor and should be stored dry and protected from light to maintain stability. It is the hydrochloride salt form of homocysteine thiolactone.