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Main Information about DSIP

Induce deep slow-wave sleep ( δ -wave sleep)

DSIP specifically enhances slow-wave activity during non-rapid eye movement (NREM) sleep, prolongs deep sleep duration, without inhibiting the central nervous system or inducing hangover-like effects.

Regulating the biological clock and circadian rhythm

The secretion of DSIP follows a circadian rhythm (increasing in the afternoon and decreasing in the early morning), which helps synchronize the hypothalamic biological clock and alleviates sleep disturbances caused by jet lag, shift work, or sleep deprivation.

Stress Response and Neuroprotection

Inhibit the excessive activation of the hypothalamic-pituitary-adrenal (HPA) axis and reduce cortisol levels.

Reduce excessive sympathetic nerve excitation and alleviate anxiety and tension

Antioxidant and anti-excitatory toxicity, protecting neurons from damage and regulating endocrine function

It can influence the secretion of growth hormone (GH), gonadotropins, and thyroid-stimulating hormone, thereby aiding in improving endocrine disorders caused by chronic stress or sleep deprivation.

Analgesic effect

Elevating the pain threshold exhibits certain alleviating effects on chronic pain and neuropathic pain.

immunoregulation

By activating the MAPK-ERK pathway in immune cells (such as lymphocytes and macrophages), it promotes cytokine secretion and enhances the body's immune function.

supplementary specification

DSIP naturally exists in the human body, primarily synthesized by the hypothalamus, and is widely distributed throughout brain tissue, cerebrospinal fluid, and plasma.

Its active form is the phosphorylated derivative (Phospho-DSIP), where the phosphorylation of serine at position 7 significantly enhances its receptor binding affinity and stability.

Although the efficacy has been clearly demonstrated in animal experiments, the results from human clinical studies are inconsistent. To date, it has not been approved as a drug by any country and is currently used solely for research purposes.