Cosmetic Ingredient Ethyl Ascorbic Acid CAS 86404-04-8 3-O-Ethyl-L-Ascorbic Acid

Vitamin C ethyl ether is a very useful vitamin C derivative. It is not only very stable in chemical substances, but also a non-discoloring vitamin C derivative, and it is a lipophilic and hydrophilic amphoteric substance, which greatly expands its Scope of application, especially in daily chemistry. 3-O-Ethyl Ascorbyl Ether can easily enter the dermis through the stratum corneum. After entering the body, it is easily decomposed by the biological enzymes in the body to exert the biological effects of vitamin C.

3-O-Ethyl-L-ascorbic acid is a stable, lipophilic derivative of vitamin C (L-ascorbic acid), where the hydrogen atom at the 3-position hydroxyl group is replaced by an ethyl group. This modification significantly enhances its stability against oxidation and improves skin penetration compared to pure ascorbic acid. It is widely used in cosmetic and skincare formulations as a highly effective and non-irritating vitamin C derivative. The compound maintains the biological activity of vitamin C after enzymatic conversion in the skin, making it a preferred choice for brightening and anti-aging products.

Unlike conventional vitamin C derivatives that require conversion into active ascorbic acid through enzymatic processes, 3-O-Ethyl-L-ascorbic acid offers a distinct advantage in formulation versatility. Its ethyl group modification not only improves lipid solubility but also enhances its ability to penetrate the stratum corneum, reaching deeper layers of the skin where it can exert antioxidant effects more efficiently. This compound remains stable in aqueous solutions across a wide pH range, reducing the formulation challenges commonly associated with pure ascorbic acid, such as discoloration and degradation. As a result, it has become a popular ingredient in high-end serums, daily moisturizers, and targeted spot treatments. Additionally, its non-irritating profile makes it suitable for sensitive skin formulations, expanding its applicability across diverse consumer demographics. From a manufacturing perspective, 3-O-Ethyl-L-ascorbic acid powder offers excellent batch-to-batch consistency and long-term storage stability, simplifying quality control and inventory management for cosmetic producers.

3-O-Ethyl-L-ascorbic acid is a white to off-white crystalline powder. It is freely soluble in water and also soluble in various organic solvents. It exhibits excellent thermal and light stability, making it suitable for different formulation conditions. The compound is non-hygroscopic and stable under normal storage conditions when kept dry and protected from light.