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Glycopyrronium bromide 51186-83-5 API

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CAS No.:

51186-83-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Packaging:

25kg/Cardboard Drum

Price valid (until):

2026-06-12

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Qingdao Orient Chemical Co.,LTD

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Location:

China

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Product Description
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Description

Product Detail

Glycopyrronium Bromide Basic information

Product Name:	Glycopyrronium Bromide
Synonyms:	erythro-Glycopyrronium bromide;Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R,S)-;Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R,S)-(+-)-;(R,S)-3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide;GlycopyrroniuM BroMide API;(3S)-3-{[(2R)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl]oxy}-1,1-dimethylpyrrolidinium bromide;Glycopyrronium bromide (CHF 5259;Glycopyrronium for peak identification (Y0001309)Q: What is Glycopyrronium for peak identification (Y0001309) Q: What is the CAS Number of Glycopyrronium for peak identification (Y0001309)
CAS:	51186-83-5
MF:	C19H28NO3.Br
MW:	0
EINECS:	209-887-0
Product Categories:
Mol File:	51186-83-5.mol

Glycopyrronium Bromide Chemical Properties

Melting point	175℃
solubility	Freely soluble in water, soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.
InChI	InChI=1/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1/t17-,19-;/s3
InChIKey	VPNYRYCIDCJBOM-SCHKGOGONA-M
SMILES	[N+]1(C)(C)CC[C@H](OC([C@](C2CCCC2)(O)C2=CC=CC=C2)=O)C1.[Br-] \|&1:5,8,r\|

Safety Information

HS Code

2933997500

MSDS Information

Glycopyrronium Bromide Usage And Synthesis

Description	Glycopyrronium bromide or NVA 237 is a once-daily inhaled antimuscarinic bronchodilator newly approved by the European Commission for use in stable COPD. It is characterized by a quaternary ammonium structure, which reduces its oral bioavailability and, consequently, the systematic effects of any swallowed portion of the drug. Animal studies suggest that there are fewer cardiovascular effects compared to tiotropium because of the higher affinity to M3 versus M2 muscarinic receptors. Human studies showed fast onset of action, sustained bronchodilatation for 24 h, reduced dynamic hyperinflation of the lungs, and improved exercise tolerance. Glycopyrronium bromide in COPD airways clinical trial series (GLOW1–3) are the major clinical trials studying the efficacy and safety of glycopyrronium[1].
Chemical Properties	White or almost white, crystalline powder.
Uses	erythro-Glycopyrronium Bromide is used in preparation of diester containing compounds for treating hyperhidrosis.
Uses	Anticholinergic
Definition	ChEBI: (2R,3S)-glycopyrronium bromide is a glycopyrronium bromide that has (2R,3S)-configuration. The racemate, ritropirronium bromide, is used for treatment of chronic obstructive pulmonary disease. It is an enantiomer of a (2S,3R)-glycopyrronium bromide.
Indications	Glycopyrronium bromide is indicated for use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions; to reduce the volume and free acidity of gastric secretions, and to block cardiac vagal inhibitory reflexes during induction of anaesthesia and intubation when indicated. Glycopyrronium bromide may be used intraoperatively to counteract drug-induced or vagal traction reflexes with the associated arrhythmias. Glycopyrronium bromide protects against the peripheral muscarinic effects (e.g., bradycardia and excessive secretions) of cholinergic agents such as neostigmine and pyridostigmine given to reverse the neuromuscular blockade due to non-depolarising muscle relaxants.
Side effects	The following reported adverse reactions are extensions of glycopyrronium bromide’s fundamentalpharmacological actions: Cardiovascular: Tachycardia, ventricular fibrillation, bradycardia, palpitation and arrhythmia, hypertension, hypotension, cardiac arrest, heart block, prolonged QTc interval. Dermatological: Flushing and inhibition of sweating. Severe allergic reactions or drug idiosyncrasies including urticaria and other dermal manifestations, pruritus, dry skin. Gastrointestinal: Nausea, vomiting, dry mouth, constipation, taste alterations, including loss of taste. Genitourinary: Urinary hesitancy and retention, impotence. Ocular: Blurred vision due to mydriasis, cycloplegia, photophobia, increased ocular tension. Nervous System: Inhibition of transmission at neuromuscular junction, headache, nervousness, drowsiness, dizziness, seizure, insomnia, some degree of mental confusion, especially in the elderly, hyperexcitability in children. Pregnancy and perinatal: Suppression of lactation. Respiratory System: Respiratory arrest. General: Hyperpyrexia, bloated feeling, anaphylaxis/anaphylactoid reaction, hypersensitivity. site reactions including pruritus, oedema, erythema, pain have been reported rarely.
References	[1] Alexander G. Mathioudakis, Victoria Chatzimavridou-Grigoriadou, Georgios A. Mathioudakis.“Chapter 16 - Drugs that act on the respiratory tract.” 2014: 241-256.

Glycopyrronium Bromide Preparation Products And Raw materials

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Basic Info

Product Name:

erythro-Glycopyrronium bromide

Other Name:

Pyrrolidinium,3-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl]oxy]-1,1-dimethyl-,bromide (1:1),(3S)-rel-;Pyrrolidinium,3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-,bromide,(R*,S*)-(±)-;Pyrrolidinium,3-[[(2R)-cyclopentylhydroxyphenylacetyl]oxy]-1,1-dimethyl-,bromide,(3S)-rel-;erythro-Glycopyrronium bromide;Ritropirronium bromide;erythro-3-Hydroxy-1,1-dimethylpyrrolidinium bromide α-cyclopentylmandelate;59677-71-3

CAS No.:

51186-83-5

Molecular Formula:

C19H28NO3.Br

InChIKeys:

InChIKey=VPNYRYCIDCJBOM-HPUDQCTANA-M

Molecular Weight:

398.341

Exact Mass:

397.12500

HScode:

2933997500

Categories:

Respiratory Drugs

Characteristics

PSA:

46.5

XLogP3:

3.37320

Melting Point:

175 °C

See More erythro-Glycopyrronium bromide Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More erythro-Glycopyrronium bromide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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