Hot Selling | Lamotrigine | 84057-84-1 | Factory Supply | Raw Materials | High Qulity | Wholesale price
TDS 1 Inquiries
84057-84-1
USP / EP / BP / JP Grade
99%
shanghai
bocare
25kg/Cardboard Drum
Yes
2026-06-19
pregabalin,Tirzepatide,Retatrutide,Food Additives,semaglutide,Cosmetics material
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceLamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for
Lamotrigine, also known by the brand name Lamictal®, is a second-generation antiepileptic drug (AED) manufactured by GlaxoSmithKline in the UK and USA. Lamotrigine is a new mazine, glutamate inhibitor anticonvulsant that significantly reduces the incidence of refractory partial seizures. The drug is reported to produce fewer CNS side effects than diazepam or sodium phenytoin. It is also indicated as add-on therapy for the treatment of generalized seizures not satisfactorily controlled by other anti-epileptics.
It is a white to cream coloured powder that is soluble in isopropanol and somewhat soluble in water. It has a melting point of 216-218°C and readily dissolves in organic solvents like benzene, toluene, and hot ethanol.
The development of lamotrigine began in the early 1980s, accidentally discovered by a group of chemists at the Wellcome Research Laboratory while searching for novel antifolate compounds. Initially synthesized as an antifolate analog, subsequent animal model screening revealed its significant anticonvulsant activity, demonstrating its potential as an antiepileptic drug. In 1980, the Wellcome Foundation filed the first synthetic method and related patent applications for lamotrigine (e.g., European Patent EP 0021121), mentioning researchers such as M. G. Baxter. During clinical development, the efficacy of lamotrigine (trade name: lamotrigine tablets) was confirmed, and it was first launched in Ireland in 1991. Subsequently, it was approved by the U.S. Food and Drug Administration (FDA) for the treatment of epilepsy in 1994. In subsequent studies, the clinical applications of lamotrigine have continued to expand, particularly its efficacy as a mood stabilizer. Researchers such as Richard H. Weissler have advanced the application of lamotrigine in the treatment of bipolar disorder, especially in the maintenance treatment of bipolar depression, through clinical observation and research.
ChEBI: Lamotrigine is a member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6. It has a role as an anticonvulsant, an antimanic drug, an antidepressant, a non-narcotic analgesic, a calcium channel blocker, an excitatory amino acid antagonist, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an environmental contaminant, a xenobiotic and a geroprotector. It is a member of 1,2,4-triazines, a primary arylamine and a dichlorobenzene.CertificatesBasic Info-
Product Name:
Lamotrigine
Other Name:4-triazine-3,5-diamine,6-(2,3-dichlorophenyl)-2;BW-430C;LAMICTAL;LAMOTRIGIN;LAMOTRIGINE;LAMOTRIGINE-13C1;GI 267119X;Lemotrigine
CAS No.:84057-84-1
Molecular Formula:C9H7Cl2N5
InChIKeys:PYZRQGJRPPTADH-UHFFFAOYSA-N
Molecular Weight:256.09
Exact Mass:256.09
EC Number:281-901-8
Color/Form:white
HScode:29336990
Categories:
Characteristics-
PSA:
90.7
XLogP3:1.4
Appearance:white powder
Density:1.572±0.06 g/cm3(Predicted)
Melting Point:177-181°C
Boiling Point:503.1±60.0 °C(Predicted)
Flash Point:9℃
Refractive Index:1.706
Water Solubility:DMSO: 20 mg/mL at 60 °C, soluble
Storage Conditions:2-8°C
Vapor Pressure:9.4X10-9 mm Hg at 25 deg C (est)
Toxicity:LD50 in mice, rats (mg/kg): 250, >640 orally (Sawyer)
PKA:5.7(at 25℃)
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 degC Keep in a dry place.
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Seller Information
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Business Type:
Trader
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Main Products:
pregabalin,Tirzepatide,Retatrutide,Food Additives,semaglutide,Cosmetics material
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Location:
Jiuzhen Town, Tianmen City, Hubei Province
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Payment Terms:
TT against copy of documents,L/C,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
$50 million-$100 million
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Total Employees:
101-200
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Year of Establishment:
2025
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Lamotrigine
1 KG Nov 2, 2025 Post an enquiry for this product
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