 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile for Sale > RU 58841 154992-24-2

RU 58841 154992-24-2

Name: RU 58841 154992-24-2
Brand: Orient
SKU: pr2605262035
Price: 44 USD
Availability: InStock

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$44-45/KG FOB

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CAS No.:

154992-24-2

Grade:

Industrail Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2027-07-31

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	RU 58841
Synonyms:	RU 58841;4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile;4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile;4-[3-(4-Hydroxybutyl)-4,4-diMethyl-2,5-dioxoiMidazolidin-1-yl]-2-(trifluoroMethyl)benzonitrile;RU-58841 E:candyli(at)speedgainpharma(dot)com;CS-637;RU 588841;RU58841;RU 58841;RU-58841
CAS:	154992-24-2
MF:	C17H18F3N3O3
MW:	369.34
EINECS:	1592732-453-0
Product Categories:	Inhibitors;154992-24-2
Mol File:	154992-24-2.mol

RU 58841 Chemical Properties

Boiling point	493.6±55.0 °C(Predicted)
density	1.39
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
form	Powder
pka	15.09±0.10(Predicted)
color	White to off-white
InChI	InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
InChIKey	ARBYGDBJECGMGA-UHFFFAOYSA-N
SMILES	C(#N)C1=CC=C(N2C(=O)N(CCCCO)C(C)(C)C2=O)C=C1C(F)(F)F

Safety Information

MSDS Information

RU 58841 Usage And Synthesis

Androgen receptor	RU58841 (PSK-3841) is a non-steroidal androgen receptor antagonist, initially intended for use in treating prostate cancer. However, it has been found to have a noteworthy impact on aiding hair regrowth. Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).
Uses	RU58841 (Roussel Uclaf) is a nonsteroidal topical antiandrogen without significant systemic effects apparently due to its metabolism in the skin. This appears to be a promising new hair growth agent that promotes hair growth on the scalp as well as retards hair growth of both beard and body hair follicles. RU58841 has produced highly efficacious results in stumptailed macaques. The synergistic effects of RU58841 and minoxidil topical solution (2% and 5%) have also been reported in stumptailed macaques. The effect of combined treatment was most remarkable early on, but by 1 year no significant benefit of combined treatment was apparent relative to either treatment alone.
Laboratory Procedures	RU-58841 is supplied as a crystalline solid. A stock solution may be made by dissolving the RU-58841 in the solvent of choice. RU-58841 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of RU-58841 is approximately33 mg/ml in ethanol and DMF and approximately 25 mg/ml in DMSO. RU-58841 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, RU-58841 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. RU-58841 has a solubility of approximately 0.16 mg/ml in a 1:5 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Side effects	Since RU58841 has not passed into phase two of drug development, there are literally no studies that have highlighted the side effects of this medication specifically. Pharmacologically speaking, there are absolutely no pharmacologic products that are 100% free of side effects. Like with every medication, RU58841 also affects each individual differently. But based on the physiologic processes it undergoes, we can hypothesize on some of its potential side effects. For instance, you should be aware that RU58841 does not only block DHT but all other androgens including testosterone.
References	1. Battmann, T., Bonfils, A., Branche, C., et al. RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. J. Steroid Biochem. Mol. Biol. 48(1), 55-60 (1994). DOI: 10.1016/0960-0760(94)90250-X 2. Obana, N., Chang, C., and Uno, H. Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology138(1), 356-361 (1997). DOI: 10.1210/endo.138.1.4890
Description	RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.

Safety Information

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

Firefighting measures

Extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile

Other Name:

Benzonitrile,4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-;4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile;RU 58841;4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile;4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-trifluoromethylbenzonitrile;RU58841

CAS No.:

154992-24-2

Molecular Formula:

C17H18F3N3O3

InChIKeys:

InChIKey=ARBYGDBJECGMGA-UHFFFAOYSA-N

Molecular Weight:

369.341

Exact Mass:

369.34

EC Number:

1592732-453-0

UNII:

0D8FJQ0ADW

DSSTox ID:

DTXSID20165781

HScode:

2933990090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

84.6

XLogP3:

2.1

Density:

1.4±0.1 g/cm3

Boiling Point:

493.6°C at 760 mmHg

Flash Point:

252.3±31.5 °C

Refractive Index:

1.560

Vapor Pressure:

1.47E-10mmHg at 25°C

See More 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

49 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	RU58841 99% powder 154992-24-2	20 G	Sep 15, 2023
Russia	RU58841 99% powder 154992-24-2	100 G	Aug 10, 2023
United States	Medical Grade Ru58841 Powder 99% 154992-24-2 API powder Ru58841	100 G	Nov 7, 2023
Croatia	High Quality 99% Purity of RU 58841 CAS NO 154992-24-2 ISO 9001:2005 REACH Verified Producer	100 G	Oct 23, 2023
United States	RU-58841	100 G	Sep 18, 2023
Portugal	Ru-58841	100 G	Apr 23, 2026
Australia	RU58841	70 G	Jun 25, 2026
United Kingdom	RU58841	100 G	Jun 17, 2026
Mexico	RU58841	10 G	Jun 6, 2026
France	RU58841	1 KG	May 26, 2026
Malaysia	SM04554	100 G	Oct 16, 2024
Democratic Republic of the Congo	Ru58841	1 MT	Sep 1, 2024
United States	Ru58841	10 G	Apr 23, 2024
United Kingdom	Ru58841	1 KG	Jan 4, 2024
Philippines	RU58841	10 G	Dec 19, 2023
Pakistan	Wuhan hhd Pharmaceutical Chemical Anti-hair loss 98% RU58841 CAS9154992-24-2 in stock 99% white powder	1 KG	Aug 23, 2023
United States	RU58841	5 KG	Aug 5, 2023
Germany	Ru58841	100 G	Jun 10, 2026
Germany	Ru58841	100 G	Jun 12, 2026
Ireland	Anti Hair Loss Ru-58841 Powder	20 G	Jun 11, 2026

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RU 58841 154992-24-2

Product Description

Seller Information

Inquiry History

First aid measures

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Firefighting measures

Extinguishing media

Specific Hazards Arising from the Chemical

Advice for firefighters

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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