Brivudine RC03332
69304-47-8
Pharmaceutical Grade
99%
Royalchem
25kg/drum
2029-12-31
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceBrivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries.|Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro.Basic Info-
Product Name:
Brivudine
Other Name:Uridine,5-[(1E)-2-bromoethenyl]-2′-deoxy-;Uridine,5-(2-bromoethenyl)-2′-deoxy-,(E)-;5-[(1E)-2-Bromoethenyl]-2′-deoxyuridine;BVDU;(E)-5-(2-Bromovinyl)deoxyuridine;(E)-5-O-(2-bromoethenyl)-2′-deoxyuridine;Brivudine;5-[(E)-2-Bromoethenyl]-2′-deoxyuridine;Helpin;(E)-5-(2-Bromovinyl)-2′-deoxyuridine;Brivudin;Bromovinyldeoxyuridine;RP 101;102040-00-6;155203-57-9;286419-83-8
CAS No.:69304-47-8
Molecular Formula:C11H13BrN2O5
InChIKeys:InChIKey=ODZBBRURCPAEIQ-PIXDULNESA-N
Molecular Weight:333.14
Exact Mass:333.14
EC Number:1806241-263-5
UNII:2M3055079H
DSSTox ID:DTXSID0045755
NCI Thesaurus Code:C67088
ATC Code:J05AB15|J - Antiinfectives for systemic use
HScode:29349990
Categories:
Characteristics-
PSA:
99.1
XLogP3:-0.4
Density:1.9±0.1 g/cm3
Melting Point:164-166 °C
Boiling Point:382.9°C at 760 mmHg
Flash Point:185.4ºC
Refractive Index:1.709
Water Solubility:Soluble in water and methanol.
Storage Conditions:2-8°C
Flammability characteristics:Thermal decomposition to emit toxic bromide and nitrogen oxide fumes
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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