High purity and high quality anti-wrinkle GHKCU copper peptide GHK Cu anti-aging raw material50mg 100mg GHK

NAME: Zoe
WHATSAPP:+852 9864 1364
EMAIL:2096860470@qq.com

    The copper peptide GHK is a tripeptide having the primary structure Gly-L-His-L-Lys. It is a natural chelator with a high affinity for  Cu2+. The resulting complex is commonly referred to as GHK-Cu. It was first isolated from human plasma, but is also present in saliva and urine.

    Copper peptides are generally small protein fragments with a high affinity for cations. Plasma GHK-Cu levels at age 20 are about 200 µg ml-1, but drop to 80 µg ml-1 at age 60. In humans, GHK-Cu promotes wound healing, stimulates glycogen and glycosaminoglycan synthesis in skin fibroblasts and blood vessel growth, has anti-inflammatory and antioxidant properties, and attracts immune system cells. Recent studies have shown that it can modulate the expression of a large number of human genes, generally by restoring the expression of these genes corresponding to the healthy state. Synthetic GHK-Cu is used in cosmetics and as an ingredient in so-called “repairing” and “anti-aging” products.

    In studies on the affinity of GHK for copper, where the histidine residue was replaced by a synthetic amino acid, it was shown that the glycine residue plays an essential role in copper binding, while the lysine residue can interact with copper only in basal. At physiological pH, lysine can interact with a cell receptor. Thanks to GHK's ability to interact with both copper and a cellular receptor, it can transport copper in and out of cells. The small size of the GHK molecule allows it to circulate rapidly in the extracellular space and easily access cellular receptors

    The structure of the GHK-Cu complex has been studied in detail by X-ray crystallography, electron paramagnetic resonance, X-ray absorption spectrometry, NMR spectroscopy or even by titration. In this complex, the Cu2+ cation is coordinated to the imidazole of the side chain of the histidine residue, and to the atom of the deprotonated peptide bond between glycine and histidine residues. Insofar as such a structure does not explain the great stability of this complex, whose decimal logarithm of the dissociation constant is worth log10(K) = 16.44, against 8.68 for the GH-Cu complex, which is similar in structure to the GHK-Cu complex, it has been suggested that another GHK atom is involved in stabilizing the complex with copper. It could be the carboxylic oxygen atom of the lysine4 residue.

    Many researchers have proposed that GHK-Cu complexes form dimers and trimers at physiological pH which may include a histidine residue and/or the copper binding region of the albumin molecule. The dissociation constant of the complex formed with copper is log10(K)=16.2 with plasma albumin versus 16.44 with GHK.

We are a chemical enterprise that integrates production, processing, and export, mainly engaged in pharmaceutical intermediates and various industrial chemicals. Since its establishment, the company has adhered to the concept of "integrity management, strict quality control, and customer first", and has won widespread praise from domestic and foreign customers. We have also established an excellent professional sales team with rich international market experience, which can efficiently provide various products and professional services.

The company focuses on synthetic biology platform technology and carries out innovative research and development, mainly engaged in peptide research and development. Its products include innovative drugs, active pharmaceutical ingredients, pharmaceutical and green synthetic industrial enzymes, functional peptides, and protein products.

At present, our company has achieved industrial production of various biosynthetic peptide products and has obtained cooperation orders from many well-known pharmaceutical companies at home and abroad.

Frequently Asked Questions

1. How to make an order?
Send me message and let me know what you need with quantity , then i will calculate to you.

2. What's the lead time and shipping ways?
We will delivery to the package by DHL or EMS express to you after receive your payment, it would take around 5-15 days to your address.

3. How do i keep the peptides when i receive it ?
Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.

4. What's the payment methods ?
We could accept pay through Wise, Bank Transfer, Alipay and alibaba

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NAME: Zoe
WHATSAPP:+852 9864 1364
EMAIL:2096860470@qq.com