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Praeruptorin B

Unit Price: Get Latest Price
CAS No.:

81740-07-0

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

  • Product Description

  • Seller Information

  • Description
    Praeruptorin B is a naturally occurring, highly bioactive pyranocoumarin derivative primarily extracted from the roots of Peucedanum praeruptorum Dunn (known as Qianhu in Traditional Chinese Medicine). Its primary functions focus on regulating lipid metabolism, working as a calcium channel blocker, and suppressing tumor metastasis and chronic inflammation. [1, 2, 3, 4, 5]
    Unlike general dietary flavonoids, praeruptorin B is considered an advanced herbal compound heavily researched for its multi-target therapeutic mechanisms in chronic metabolic and respiratory conditions. [1, 2]
    Core Health Functions
    • Lowers Intracellular Lipids: It functions as a novel inhibitor of SREBPs (Sterol Regulatory Element-Binding Proteins), which are nuclear transcription factors that dictate fat synthesis. By regulating the PI3K/Akt/mTOR pathway, it significantly blocks lipid deposition, improves hyperlipidemia, and alleviates insulin resistance. [1]
    • Acts as a Calcium Antagonist: It exerts strong calcium channel blocking activity. This blocks the influx of calcium ions into smooth muscle cells, directly promoting vasorelaxation (widening of blood vessels) and relieving respiratory or cardiovascular spasms. [1, 2, 3, 4]
    • Mitigates Tumor Metastasis: In oncology research, it prevents cancer cells from invading healthy tissues. It suppresses the metastatic ability of highly aggressive lines (like human renal carcinoma) by selectively targeting and downregulating certain cellular proteinases. [1, 2]
    • Inhibits Bone Breakdown (Osteoclastogenesis): It acts as an anti-osteoclastogenic agent by targeting specific cellular enzymes (like GSTP1) and suppressing the NF-κB signaling pathway. This action stops the excessive formation and activity of osteoclasts (cells that degrade bone tissue). [1, 2, 3, 4]
    • Relieves Respiratory Spasms: By relaxing bronchial smooth muscles, it supports the traditional use of its parent herb to combat asthma, chronic coughs, and severe pulmonary congestion. [1, 2, 3, 4, 5]

    Basic Info
    Product Name:

    Praeruptorin B

    Other Name:

    (+)Pareruptorin B;[8,8-Dimethyl-9-[(E)-2-methylbut-2-enoyl]oxy-2-oxo-9,10-dihydropyrano[6,5-h]chromen-10-yl] (E)-2-methylbut-2-enoate;Praeruptorin B;[8,8-dimethyl-9-[(E)-2-methylbut-2-enoyl]oxy-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl] (E)-2-methylbut-2-enoate;Praeruptorin B 81740-07-0;Paeruptorin B;Praeruptorin B, 98%, from Peucedanum praeruptorum Dunn;14-Tetradecanedicarboxylic acid

    CAS No.:

    81740-07-0

    Molecular Formula:

    C24H26O7

    InChIKeys:

    PNTWXEIQXBRCPS-FNCQTZNRSA-N

    Molecular Weight:

    426.46

    Exact Mass:

    426.46

    Color/Form:

    Off-White

    HScode:

    29389090

    Categories:

    Plant Extracts

    Characteristics
    PSA:

    92.04000

    XLogP3:

    5.99

    Density:

    1.2±0.1 g/cm3

    Melting Point:

    179-181°C

    Boiling Point:

    524.8±50.0 °C at 760 mmHg

    Flash Point:

    225.5±30.2 °C

    Refractive Index:

    1.573

    Critical Temperature & Pressure:

    Amber Vial, -20°C Freezer, Under inert atmosphere

    Hazard Identification

    Classification of the substance or mixture

    no data available

    GHS label elements, including precautionary statements

    Pictogram(s) no data available
    Signal word

    no data available

    Hazard statement(s)

    no data available

    Precautionary statement(s)
    Prevention

    no data available

    Response

    no data available

    Storage

    no data available

    Disposal

    no data available

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

    Location:

    Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    51-100

    Year of Establishment:

    2019

  • Country Product Purchase Quantity Date Posted
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