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Loganin

Name: Loganin
Brand: Cuicheng Bio
SKU: pr2606011578
Price: 2000 USD
Availability: InStock

Unit Price: Get Latest Price 

CAS No.:

18524-94-2

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Details
Seller Information

Description

Loganin is a highly active, plant-derived iridoid glycoside that functions primarily as a neuroprotective, anti-inflammatory, and kidney-protective agent. Found abundantly in traditional medicinal plants like Cornus officinalis (Asiatic cornelian cherry/Shanzhuyu), its fundamental biological role is shielding vulnerable nerve and organ tissues from advanced oxidative damage and cellular death (apoptosis).

In the landscape of plant bioactive compounds, while flavonoids like quercetin or kaempferol operate largely as general antioxidant scavengers, loganin acts as a highly specialized enzyme and transcription pathway modulator.

Core Health Functions

Protects Brain Cells & Enhances Memory: It easily crosses the blood-brain barrier to reduce neuroinflammation by halting microglia activation. In preclinical models of cognitive decline, loganin dramatically reduces amyloid-beta ($A\beta$) plaque deposition and decreases phosphorylated tau proteins, helping to rescue severe memory deficits. [1, 2, 3, 4, 5]
Suppresses "Inflammaging" and Pain Signaling: It dampens chronic pain by blocking the NF-κB signaling cascade and reducing downstream pro-inflammatory cytokines like TNF-$\alpha $, IL-1$\beta $, and IL-6. This function makes it uniquely effective at alleviating neuropathic pain, such as painful diabetic neuropathy. [1, 2, 3, 4, 5]
Safeguards Kidney and Liver Health: In traditional medicine, its parent plants are used to "nourish the liver and kidneys". Science confirms that loganin blocks the JAK2/STAT3 pathway and suppresses the accumulation of Advanced Glycation End-products (AGEs), significantly lowering the risk of diabetic nephropathy (kidney disease). [1, 2, 3]
Activates Cellular Antioxidant Defenses: Rather than just directly absorbing free radicals, loganin upregulates the Nrf2/HO-1 signaling axis. This commands the body's cells to massively ramp up their own internal production of protective enzymes, such as Superoxide Dismutase (SOD) and Glutathione (GSH). [1, 2]
Reverses Mitochondrial Dysfunction & Pyroptosis: Recent testing highlights loganin’s ability to stabilize mitochondrial energy production and inhibit the NLRP3 inflammasome. This mechanism stops cells (particularly nerve-insulating Schwann cells) from undergoing inflammatory, premature cell suicide (pyroptosis)

ECHEMI Editorial Reference

Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects. Loganin exhibits an anti-inflammatory effect in cases of AP and its pulmonary complications through inhibition of NF-κB activation.
Loganin is an iridoid monoterpenoid with formula C17H26O10 that is isolated from several plant species and exhibits neuroprotective and anti-inflammatory properties. It has a role as a plant metabolite, a neuroprotective agent, an EC 3.4.23.46 (memapsin 2) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an anti-inflammatory agent and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a cyclopentapyran, a beta-D-glucoside, an enoate ester, a monosaccharide derivative, an iridoid monoterpenoid, a methyl ester and a secondary alcohol.

Basic Info

Product Name:

(-)-Loganin

Other Name:

Cyclopenta[c]pyran-4-carboxylic acid,1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-,methyl ester,(1S,4aS,6S,7R,7aS)-;Loganin;Cyclopenta[c]pyran-4-carboxylic acid,1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-,methyl ester,[1S-(1α,4aα,6α,7α,7aα)]-;Cyclopenta[c]pyran-4-carboxylic acid,1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-,methyl ester;(1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-6α-hydroxy-7α-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester;7-Hydroxy-6-desoxyverbenalin;Loganoside;(-)-Loganin;NSC 606403;1416-12-2;28629-68-7

CAS No.:

18524-94-2

Molecular Formula:

C17H26O10

InChIKeys:

InChIKey=AMBQHHVBBHTQBF-UOUCRYGSSA-N

Molecular Weight:

390.38

Exact Mass:

390.38

EC Number:

242-398-0

UNII:

H7WJ16Q93C

HScode:

29389090

Categories:

Chinese Herbs

Characteristics

PSA:

155

XLogP3:

-1.4

Appearance:

White Powder

Density:

1.5±0.1 g/cm3

Melting Point:

223 °C

Boiling Point:

608.8°C at 760 mmHg

Flash Point:

217.9±25.0 °C

Refractive Index:

1.600

Storage Conditions:

Keep container tightly closed.

Vapor Pressure:

2.31E-17mmHg at 25°C

Specific rotation:

D20 -82.1° (water)

Collision Cross Section:

195.65 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|194.4 Å² [M+Na]+

See More (-)-Loganin Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More (-)-Loganin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Loganin

Product Details

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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