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Formononetin

Name: Formononetin
Brand: Cuicheng Bio
SKU: pr2606011583
Price: 10000 USD
Availability: InStock

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CAS No.:

485-72-3

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information
Inquiry History

Description

Formononetin (CAS Number: 485-72-3) is a natural O-methylated isoflavone compound (phytoestrogen) found abundantly in legumes such as Red Clover (Trifolium pratense), Astragalus membranaceus, and Licorice (Glycyrrhiza glabra).

It functions as a highly active, multi-target research tool, a premium cosmetic ingredient, and a functional botanical bioactive, widely celebrated for its selective estrogenic receptor modulation, tissue-repairing pro-angiogenic actions, antitumor properties, and bone protection.

Key Pharmacological Functions and Mechanisms

Selective Estrogen Receptor Modulation (SERM Activity): Structurally mimicking endogenous 17$\beta $-estradiol, formononetin binds selectively to human estrogen receptors, showing a higher binding affinity for $\text{ER}\beta$ than $\text{ER}\alpha$. This distinct activation allows it to exert mild estrogenic benefits in target tissues (like bones and the nervous system) without hyper-stimulating $\text{ER}\alpha$-dense reproductive tissues, making it a valuable candidate for managing postmenopausal symptoms.
Promotion of Microvascular Angiogenesis & Wound Healing: Unlike many other flavonoids that act as anti-angiogenic agents, formononetin exhibits strong pro-angiogenic properties at specific biological concentrations. It activates the Egr-1/VEGF-A signaling axis and the MAPK/ERK pathway, accelerating vascular endothelial cell proliferation, migration, and tube formation. In preclinical models, its topical application significantly speeds up chronic wound healing, skin ulcers, and ischemic tissue repair.
Antitumor Activity and Prodrug Properties: In cancer biology, formononetin demonstrates selective cytotoxicity against various malignant lines, including breast, prostate, colorectal, and osteosarcoma cancers. It shuts down the PI3K/Akt/mTOR and STAT3 signaling cascades to induce cell cycle arrest at the G0/G1 phase and spark mitochondrial apoptosis.
- Metabolic Prodrug Nature: When taken orally, formononetin is rapidly demethylated in the liver by Cytochrome P450 enzymes (mainly CYP1A2 and CYP2C9), metabolizing into the highly potent compounds daidzein and equol.
Targeted Anti-Inflammatory Action and Nrf2 Activation: It downregulates systemic inflammation by blocking the NF-$\kappa\text{B}$ pathway and activating AMPK. This suppresses the induction of iNOS and COX-2 enzymes and curtails the release of pro-inflammatory cytokines like TNF-$\alpha $ and IL-6. Concurrently, it upregulates the Nrf2-mediated antioxidant defense system to shield organs from ischemia-reperfusion injuries.
Prevention of Bone Loss (Anti-Osteoporotic Effect): Formononetin significantly stimulates osteoblast differentiation and bone mineralization by increasing osteoprotegerin (OPG) expression. Simultaneously, it shuts down osteoclast-mediated bone resorption via the inhibition of RANKL signaling networks, making it highly effective at protecting bone density in postmenopausal models.
Metabolic and Lipid Regulation: Acting as a natural ligand modifier for PPAR$\gamma $, it enhances peripheral insulin sensitivity and accelerates lipid $\beta $-oxidation. This significantly reduces total serum lipid spikes and prevents hepatic steatosis (triglyceride accumulation in the liver).

Cosmetic and Industrial Functions

Scalp Care and Anti-Hair Loss Formulations: In premium hair care and scalp serums, formononetin serves as a core active ingredient. Because it combines local microvascular circulation enhancement (via angiogenesis) with mild anti-inflammatory and anti-follicular aging actions, it effectively nourishes hair follicles, improves root anchors, and aids in preventing premature hair loss.
Quality Control Reference Standard: Because it represents a foundational active component in Astragalus and Red Clover, analytical testing laboratories rely heavily on it as an official HPLC analytical standard to authenticate raw herbal matrices and standardize industrial botanical extracts.

Basic Info

Product Name:

Formononetin

Other Name:

4H-1-Benzopyran-4-one,7-hydroxy-3-(4-methoxyphenyl)-;Formononetin;Isoflavone,7-hydroxy-4′-methoxy-;7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;7-Hydroxy-4′-methoxyisoflavone;Biochanin B;Formononetol;Daidzein 4′-methyl ether;NSC 93360;Flavosil;Formonetin;7-Hydroxy-3-(4-methoxyphenyl)chromen-4-one;Myconate;Formonentin;6-Demethoxyafromosin;Mycotech;Myconate HB;Neochanin

CAS No.:

485-72-3

Molecular Formula:

C16H12O4

InChIKeys:

InChIKey=HKQYGTCOTHHOMP-UHFFFAOYSA-N

Molecular Weight:

268.26400

Exact Mass:

268.26

EC Number:

207-623-9

UNII:

295DQC67BJ

NSC Number:

93360

DSSTox ID:

DTXSID4022311

HScode:

2932999099

Categories:

Skin Protecting

Characteristics

PSA:

59.67000

XLogP3:

2.8

Appearance:

Solid

Density:

1.329 g/cm3

Melting Point:

256.5 °C

Boiling Point:

479.4ºC at 760 mmHg

Flash Point:

183.4±22.2 °C

Refractive Index:

1.641

Water Solubility:

157.3 mg/L @ 25 °C (est)

Storage Conditions:

Store in a cool, dry place. Store in a tightly closed container.

Vapor Pressure:

8.17E-10mmHg at 25°C

Collision Cross Section:

176.14 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|169.04 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|156.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|168.5 Å² [M-H]-

See More Formononetin Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Formononetin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Formononetin	8 G	Dec 25, 2023

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Product Name	Grade / Content	Supplier Name	Details
China Most Professional Factory Supply High Qulity Formononetin CAS 485-72-3	Pharmaceutical Grade/99	LEADER BIOCHEMICAL GROUP	Inquiry
485-72-3 Formononetin	/	ChenLv Herb Extract	Inquiry
Formononetin	/99.00	HANGZHOU LEAP CHEM CO., LTD.	Inquiry
Formononetin	industrial Grade/98	Hangzhou KieRay Chem Co.,LTD	Inquiry
Formononetin	Pharmaceutical grade/0.99	Xian ZB Biotech Co.,Ltd	Inquiry

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Formononetin

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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