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Caffeic acid

Name: Caffeic acid
Brand: Cuicheng Bio
SKU: pr2606011589
Price: 100 USD
Availability: InStock

6 Inquiries

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CAS No.:

331-39-5

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information
Inquiry History

Description

Caffeic acid (CAS Number: 331-39-5) is a natural hydroxycinnamate derivative (phenolic acid) found abundantly in coffee, tea, dandelion, propolis, and various fruits and vegetables. It serves as a core structural precursor for the synthesis of more complex polyphenols, such as chlorogenic acid.

It functions as a highly active, multi-target research tool, a premium cosmetic bioactive, and a functional ingredient in the pharmaceutical and food industries, celebrated for its antioxidant, anti-inflammatory, antitumor, and skin-brightening properties.

Key Pharmacological Functions and Mechanisms

Exceptional Antioxidant Action via Nrf2 Activation: Featuring a catechol (ortho-dihydroxyl) moiety on its phenyl ring, caffeic acid possesses superior electron-donating properties. It directly traps reactive oxygen species (ROS) and free radicals, effectively blocking cellular lipid peroxidation and the oxidation of LDL cholesterol. Concurrently, it activates the Nrf2/ARE signaling pathway, heavily upregulating endogenous protective enzymes such as superoxide dismutase (SOD) and heme oxygenase-1 (HO-1).
Selective 5-Lipoxygenase (5-LOX) & NF-$\kappa\text{B}$ Inhibition: Caffeic acid is historically celebrated as a selective inhibitor of 5-lipoxygenase (5-LOX). By blocking 5-LOX, it specifically shuts down the biosynthesis of pro-inflammatory leukotrienes, making it highly effective at mitigating edema, allergic reactions, and acute inflammatory responses. It also inhibits the NF-$\kappa\text{B}$ pathway, downregulating iNOS and COX-2 to curb the release of cytokines like TNF-$\alpha $ and IL-6.
Antitumor Activity and Suppression of Angiogenesis: In tumor biology, it exerts direct cytotoxicity against colorectal, breast, skin, and glioblastoma cancer cell lines. It disrupts PI3K/Akt and MAPK/ERK signaling cascades to induce cell cycle arrest and mitochondrial apoptosis. Additionally, it downregulates matrix metalloproteinases (MMP-2 and MMP-9) and Vascular Endothelial Growth Factor (VEGF) to restrict tumor invasion and blood vessel formation (angiogenesis).
Cardiovascular and Endothelial Protection: It shields blood vessels by enhancing endothelial nitric oxide synthase (eNOS) expression. This promotes nitric oxide (NO) generation, which helps relax vascular smooth muscle, improve microcirculation, and regulate blood pressure. It also prevents abnormal platelet aggregation to guard against thrombosis.
Antiviral and Immunomodulatory Actions: Caffeic acid modulates T-cell activation and macrophage functions. It interferes with the cellular replication cycles of several viral strains, including herpes simplex and influenza viruses.

Cosmetic and Industrial Functions

UV Photoprotection and Tyrosinase Inhibition (Skin Brightening): In advanced skincare formulations, it acts as an effective anti-photoaging agent by absorbing ultraviolet radiation (specifically UVB) and safeguarding dermal fibroblasts from light-induced damage. Furthermore, it competitively inhibits tyrosinase activity, blocking the formation of dopaquinone to suppress excessive melanin synthesis and fade hyperpigmentation.
Quality Control Reference Standard: Because it is a foundational active component in many traditional herbs (such as dandelion and honeysuckle), analytical laboratories heavily rely on it as an official HPLC reference standard to authenticate plant materials and standardize herbal extracts.

Basic Info

Product Name:

Caffeic acid

Other Name:

2-Propenoic acid,3-(3,4-dihydroxyphenyl)-;Cinnamic acid,3,4-dihydroxy-;3-(3,4-Dihydroxyphenyl)-2-propenoic acid;Caffeic acid;3,4-Dihydroxycinnamic acid;3-(3,4-Dihydroxyphenyl)propenoic acid;4-(2-Carboxyethenyl)-1,2-dihydroxybenzene;4-(2′-Carboxyvinyl)-1,2-dihydroxybenzene;3,4-Dihydroxybenzeneacrylic acid;NSC 57197;NSC 623438;DHCA

CAS No.:

331-39-5

Molecular Formula:

C9H8O4

InChIKeys:

InChIKey=QAIPRVGONGVQAS-UHFFFAOYSA-N

Molecular Weight:

180.15700

Exact Mass:

180.16

EC Number:

206-361-2

HScode:

2942000000

Categories:

Fragrance Ingredient

Characteristics

PSA:

77.76000

XLogP3:

1.2

Appearance:

yellow to tan powder

Density:

1.478 g/cm3

Melting Point:

225 °C (decomp)

Boiling Point:

416.8ºC at 760 mmHg

Flash Point:

220ºC

Refractive Index:

1.707

Water Solubility:

Sparingly soluble in cold water. Freely soluble in hot water, cold alcohol.

Storage Conditions:

Store at RT.

PKA:

4.62(at 25 °C)

See More Caffeic acid Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

Carcinogenicity, Category 2

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Caffeic acid Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019

Inquiry History

6 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Caffeic acid	5.00 KG	Apr 2, 2026
Argentina	caffeic acid	50 G	Jan 7, 2026
India	Caffeic acid	50.00 KG	Mar 30, 2026
United States	Caffeic Acid	100 KG	Oct 7, 2025
United States	caffeic acid	5 KG	Jun 3, 2025
Bangladesh	Butyl Acetate	1.00 KG	Nov 11, 2025

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Caffeic acid

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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More Choices Find All Products for Sale 

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